JCEG ID JCEG159
Name hst-3.2      WormBase
Human Ortholog

GGDB:HS3ST3A1 HS3ST3B1 HS3ST2 HS3ST4 HS3ST5 HS3ST6 

OMIM: 604056 604057 604058 604059

OrthoList :   HS3ST3B1   HS3ST3A1   HS3ST6   HS3ST4   HS3ST2  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.000002 24324551
MAPPED 0.0000007 0.0437 (unit increase) [NR] 24086445
MAPPED 0.381 0.000004 (Dominant model) 1.647 [1.264-2.146] 23648065
UPSTREAM 0.2 0.000001 1.19 [NR] 19525955
DOWNSTREAM 0.04 0.000002 0.082 (unit increase)] 22823124
GGDB Score E-val
HS3ST3A1 281 9e-78
HS3ST3B1 281 9e-78
HS3ST4 265 8e-73
HS3ST2 261 9e-72
HS3ST5 227 1e-61
HS3ST1 218 8e-59
NDST4 147 2e-37
NDST3 140 2e-35
NDST2 137 3e-34
NDST1 134 1e-33
GALNAC4S-6ST 56 9e-10
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Sulfotransferase and sulfation-related genes
Locus Tag F52B10.2
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Bhattacharya R, Townley RA, Berry KL, Bulow HE J. Cell. Sci. (2009) 122 (Pt 24) :4492-504 [PMID : 19920077] The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Attreed M, Desbois M, van Kuppevelt TH, Bulow HE Nat. Methods (2012) 9 (5) :477-9 [PMID : 22466794] Direct visualization of specifically modified extracellular glycans in living animals.

Tecle E, Diaz-Balzac CA, Bulow HE G3 (Bethesda) (2013) 3 (3) :541-52 [PMID : 23451335] Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.

WormBase (WS254)

Functional Descriptions hst-3.2

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003672

epithelial cell "cell of epithelium, the layer of cells that cover the external surface of an organism as well as forming an inner lining between the tissues and organs of that organism and the external environment. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells." [WB:rynl, WBPaper:00038216] Certain WB:Expr10714 WBPaper00041895
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Certain WB:Expr10714 WBPaper00041895 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Partial WB:Expr10714 WBPaper00041895 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Certain WB:Expr11889 WBPaper00045532 WormAtlas
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00037950 : A-class-motor-neurons_larva_SelectivelyEnriched, A-class-motor-neurons_larva_enriched
WBPaper00037950
WB WBbt:0005339

VA neuron "Neuron class of twelve motoneurons, distributed along the ventral cord, which innervate ventral body muscles." [WB:Paper00000938] Enriched WBPaper00037950 : A-class-motor-neurons_larva_SelectivelyEnriched, A-class-motor-neurons_larva_enriched
WBPaper00037950
WB WBbt:0005733

hypodermis "epidermal layer" [WB:pws] Certain WB:Expr10714 WBPaper00041895
WB WBbt:0005796

intestinal muscle "intestinal muscle cell, attach to intestine and body wall anterior to anus" [WB:Paper00000653] Uncertain WB:Expr10714 WBPaper00041895 WormAtlas
WB WBbt:0006746

dopaminergic neuron "Neuron that uses dopamine (DA) as a neurotransmitter." [WB:rynl] Enriched WBPaper00037950 : dopaminergic-neurons_larva_SelectivelyEnriched, dopaminergic-neurons_larva_enriched
WBPaper00037950
WB WBbt:0006748

vulva "female genital." [WB:rynl] Certain WB:Expr10714 WBPaper00041895 WormAtlas
WB WBbt:0006819

AVE "Neuron class of two interneurons with cell bodies situated in the lateral ganglion close to the ring neuropile." [WB:Paper00000938] Enriched WBPaper00037950 : AVE-neuron_embryo_SelectivelyEnriched, AVE-neuron_embryo_enriched
WBPaper00037950

WBGene00044303
Phenotype
Homology_paralog



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