JCEG ID JCEG136
Name stt-3      WormBase
Human Ortholog

GGDB:STT3 

OMIM: 608605 615597

OrthoList :   STT3B  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.884 0.0000009 (Modelling analysis) 23453885
MAPPED 0.88 0.000001 1.1 [1.06-1.14] 21926974
Family Name Oligosaccharyltransferase complex
Locus Tag T12A2.2
RNAi phenotype
phenotype small, oocyte morphology variant (95% n=20, see reference), hsp-4::GFP increase
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)

Increase

Sequence Features
Sequence CDS
Protein
References

Gonczy P, Echeverri C, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlu N, Bork P, Hyman AA Nature (2000) 408 (6810) :331-6 [PMID : 11099034] Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.

Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.

Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH PLoS Biol. (2003) 1 (1) :E12 [PMID : 14551910] Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.

Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Yoshina S, Sakaki K, Yonezumi-Hayashi A, Gengyo-Ando K, Inoue H, Iino Y, Mitani S Mol. Biol. Cell (2012) 23 (9) :1728-41 [PMID : 22419820] Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi.

Shi Z, Ruvkun G Proc. Natl. Acad. Sci. U.S.A. (2012) 109 (12) :4568-73 [PMID : 22396595] The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.

Winter JF, Hopfner S, Korn K, Farnung BO, Bradshaw CR, Marsico G, Volkmer M, Habermann B, Zerial M Nat. Cell Biol. (2012) 14 (7) :666-76 [PMID : 22634595] Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.

WormBase (WS254)

Functional Descriptions stt-3

Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005662

AFD "Neuron class of two ciliated neurons that are part of the amphid sensillum; the endings of AFD have numerous villi, which poke into the amphid sheath cells." [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005671

AWB "Neuron class of two ciliated neurons with flattened, sheet-like endings that are associated with the sheath cells of the amphid sensilla" [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671

WBGene00020437
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
cell membrane organization biogenesis variant

"Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
chromosome condensation variant

"Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
diakinesis progression during oogenesis variant

"Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
diplotene progression during oogenesis variant

"Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
diplotene region organization variant

"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
embryo osmotic integrity defective early emb

"Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141]
RNAi: WBRNAi00053155   WBPaper00025054   Observed
RNAi: WBRNAi00053156   WBPaper00025054   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00002457   WBPaper00004403   Observed
RNAi: WBRNAi00002790   WBPaper00004403   Observed
RNAi: WBRNAi00009159   WBPaper00005654   Observed
RNAi: WBRNAi00026276   WBPaper00006395   Observed
RNAi: WBRNAi00053155   WBPaper00025054   Observed
RNAi: WBRNAi00053156   WBPaper00025054   Observed
germ cell compartment expansion variant

"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
germ cell compartment large

"Germ cell compartments are larger than that of control animals." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
germ cell compartment morphology variant

"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
germ cell compartment size variant

"Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
germline nuclear positioning variant

"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
gonad vesiculated

"Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00026276   WBPaper00006395   Observed
locomotion variant

"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
RNAi: WBRNAi00026276   WBPaper00006395   Observed
long

"Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31]
RNAi: WBRNAi00009159   WBPaper00005654   Observed
lysosome-related organelle morphology variant

"Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
RNAi: WBRNAi00090784   WBPaper00041129   Observed
maternal sterile

" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
RNAi: WBRNAi00009159   WBPaper00005654   Observed
nuclear appearance variant

"The morphological appearance of nuclei differs from control animals." [WB:cab]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
oocyte septum formation variant

"Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
RAB-11 recycling endosome morphology variant

"Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
RNAi: WBRNAi00090784   WBPaper00041129   Observed
rachis morphology variant

"Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
sterile

"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
RNAi: WBRNAi00085407   WBPaper00038381   Observed
thin

"Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712]
RNAi: WBRNAi00026276   WBPaper00006395   Observed
transgene subcellular localization variant

"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
RNAi: WBRNAi00090784   WBPaper00041129   Observed


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