JCEG ID JCEG135
Name ogt-1      WormBase    NCBI Gene
Human Ortholog

GGDB:OGT 

OMIM: 300255

OrthoList :   OGT  (Ensembl Compara)

GGDB Score E-val
OGT 1434 0.0
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name O-GlcNAcT
Locus Tag K04G7.3
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features tm:soluble
dxd:Detected
gg_motif:M1, M2, M3, M6
Sequence CDS
Protein
References

Kreppel LK, Blomberg MA, Hart GW J. Biol. Chem. (1997) 272 (14) :9308-15 [PMID : 9083067] Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats.

Lubas WA, Frank DW, Krause M, Hanover JA J. Biol. Chem. (1997) 272 (14) :9316-24 [PMID : 9083068] O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats.

Hanover JA, Forsythe ME, Hennessey PT, Brodigan TM, Love DC, Ashwell G, Krause M Proc. Natl. Acad. Sci. U.S.A. (2005) 102 (32) :11266-71 [PMID : 16051707] A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ J. Biol. (2007) 6 (3) :8 [PMID : 17897480] A global analysis of genetic interactions in Caenorhabditis elegans.

Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, Banyai L, Patthy L BMC Bioinformatics (2008) 9 :353 [PMID : 18752676] Identification and correction of abnormal, incomplete and mispredicted proteins in public databases.

Kwon SI, Kim SH, Bhattacharjee S, Noh JJ, Gassmann W Plant J. (2008) 57 (1) :109-19 [PMID : 18774967] SRFR1, a suppressor of effector-triggered immunity, encodes a conserved tetratricopeptide repeat protein with similarity to transcriptional repressors.

Lee J, Kim KY, Lee J, Paik YK J. Biol. Chem. (2009) 285 (5) :2930-9 [PMID : 19940149] Regulation of Dauer formation by O-GlcNAcylation in Caenorhabditis elegans.

Rahman MM, Stuchlick O, El-Karim EG, Stuart R, Kipreos ET, Wells L Aging (Albany NY) (2010) 2 (10) :678-90 [PMID : 20952811] Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW Genetics (2011) 188 (2) :369-82 [PMID : 21441213] O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.

WormBase (WS254)

Functional Descriptions ogt-1

ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.
Deletion Mutants gk2567 tm1046 ok1474 ok430
In Situ clone=46a1   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Certain WB:Expr12076 WBPaper00046045 WormAtlas
WB WBbt:0005662

AFD "Neuron class of two ciliated neurons that are part of the amphid sensillum; the endings of AFD have numerous villi, which poke into the amphid sheath cells." [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005671

AWB "Neuron class of two ciliated neurons with flattened, sheet-like endings that are associated with the sheath cells of the amphid sensilla" [WB:Paper00000938] Enriched WBPaper00024671 : AFD_AWB_vs_unsorted_upregulated
WBPaper00024671
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Certain WB:Expr12076|WB:Expr12077 WBPaper00046045 WormAtlas
WB WBbt:0005812

excretory cell "H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] Enriched WBPaper00037950 : excretory-cell_larva_enriched
WBPaper00037950 WormAtlas
WB WBbt:0006746

dopaminergic neuron "Neuron that uses dopamine (DA) as a neurotransmitter." [WB:rynl] Enriched WBPaper00037950 : dopaminergic-neurons_larva_enriched
WBPaper00037950
WB WBbt:0006831

PVD "Neuron class of two interneurons with cell bodies situated laterally in the posterior body." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375
WB WBbt:0006847

OLL "Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938] Enriched WBPaper00036375 : enriched_in_PVD_OLL
WBPaper00036375
WB WBbt:0007846

hypodermal cell "primary cell type that forms the hypodermis." [WB:rynl] Certain WB:Expr12076 WBPaper00046045

WBGene00003858
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
carbohydrate metabolism variant

"Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712]
Allele: WBVar00091724   WBPaper00038233   Observed
drug resistant

"Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557]
Allele: WBVar00091724   WBPaper00035502   Observed
organism development variant

"Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab]
RNAi: WBRNAi00067879   WBPaper00031036   Observed
RNAi: WBRNAi00067955   WBPaper00031036   Observed
organism heat hypersensitive

"Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557]
Allele: WBVar00091724   WBPaper00045080   Observed
organism stress response variant

"Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712]
Allele: WBVar00091724   WBPaper00038233   Observed
Allele: WBVar00092687   WBPaper00038233   Observed
Allele: WBVar00250065   WBPaper00038233   Observed
pheromone induced dauer formation defective

"Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
Allele: WBVar00091724   WBPaper00035502   Observed
protein expression reduced

"Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva]
Allele: WBVar00091724   WBPaper00035502   Observed
protein modification variant

"Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021]
Allele: WBVar00091724   WBPaper00035502   Observed
Allele: WBVar00250065   WBPaper00038233   Observed


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