| JCEG ID |
JCEG133 |
| Name |
lge-1
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:LARGE
OMIM:
603590
605517
608840
609709
613154
615287
OrthoList :
LARGE
GYLTL1B
(Ensembl Compara)
GWAS Catalog
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.56 |
0.000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| DOWNSTREAM |
0.54 |
0.0000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.28 |
0.000008
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.11 |
0.000008
|
1.44
|
|
[1.28-1.60] |
24962325
|
|
Kapoor M 2014-06-11 Drug Alcohol Depend
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
LARGE |
| Locus Tag |
K09C8.4
|
| RNAi phenotype |
|
phenotype
|
WT
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
Normal
|
|
hsp-4::GFP (Image)
|
|
|
| Sequence Features |
tm:soluble
dxd:Detected
gg_motif:M1, M2, M4, M5, M6
|
| Sequence |
CDS
atgcaatcaaactatagtatatcatattttctattaatcctcttcacagg
aacttcgtcatattttacaatatggaactttgtggaccacacacgtgttg
gggcgtttccggaagaagattacattcgccttgcgtatattatcggtgga
aattttatgacacgtcttatgttcatgcagcattttaaaagtgtattgaa
gtactctgaccatttctttcgcctacatctgataactgatgaaaatcacc
gatccgatattcatgagctcatgacgtcatggaatatttcaaactgcgag
tggttttttcacaatctcacagagttcgaaaaacgagttgcttggattcc
aaattcacattattcaaaatattatggtttgagcaaacttttaattcctg
aaatcatcggcaatgacattggaaagattatgttcatggatgttgatatc
atttttcaaaccaatatttttgatttgtggaaacaatttagaaactttaa
caattcccaggttttcggaatggtggaaaatctttccgattggtatctta
acaaggatggtaaaaagtcggtttggccagcattgggacgtggatttaac
actggaataatcatgtttgatttggataagctccggaaaaatggatgggc
aagcaaatggagagtagtggctaacaaatatttacgaattcacggaaaaa
ctgccatgtcagatcaagacatatttaatgcatacattcatgactatccg
actgaaattatacaaattccatgtgcttacaattatcaacttggagcact
cacaaaatccaaagaactatgtccggagactccacttgcgctacatttca
actcacaaaacaagactgttggaaaaaattacgcattttttgacaagatt
cgaaaagcgtttgatgaaatggatggttcagatcttaaacgacgtagacg
atcttttaaaggaaataatcaaaaagatatctgccatgaatatttaccat
tagacaatttccgaattatcccaaatgcaattggaagaatgacaaaacct
gcagaactctgcatggtgacgcagttttccaaagatcgacttaatcattt
tctggaaagtgcaaatgcgtggcggcatcctatatctacagcagtatacg
ggaaggataaagatttgctagacattgcaaaagccgtcacagaattgaat
cgcacagatatcacaatccatctggtttttgaggaaccaactgaatcctg
gatgctagactctttatatcccataaattttttgagaaatgtagcaattg
aacacgcaaactgcaaatatattttaatgactgatgtagattttgtggta
cttggagattacggtacaataatcgatcaaactggaaacctgaaacaaaa
agaagttctggtgatccctgcattggaaatgacatacccgcagctgaggt
taaatttatcaaattttctctcgagaaaagatttggtgatagaacattta
ttgaacaaaaccattcaaacttttcgggaaacaatttggccaagttctca
cgtacctacaaatatttcaaaatggataaagtcaaatcgcacttatatgg
taaattatgaaaagaactatgaaccttattttgtaatcaaaaaagaagaa
tgccctttttacgatcagcggttcggaggatttggctggaataaagtaac
tcatgtaatgcaactgaaaatgatgaattataagttcttggtttctccaa
ctagttttatgattcatcaaaatcataatgcttcaaaatcattgaaacgc
tggagacgtgacccacattatcagaaatgccttcacacgttaaaaaataa
atttatgaaaaaaactgctagtcgactgggaatcaagctaagatga
|
Protein
MQSNYSISYFLLILFTGTSSYFTIWNFVDHTRVGAFPEEDYIRLAYIIGGNFMTRLMFMQ
HFKSVLKYSDHFFRLHLITDENHRSDIHELMTSWNISNCEWFFHNLTEFEKRVAWIPNSH
YSKYYGLSKLLIPEIIGNDIGKIMFMDVDIIFQTNIFDLWKQFRNFNNSQVFGMVENLSD
WYLNKDGKKSVWPALGRGFNTGIIMFDLDKLRKNGWASKWRVVANKYLRIHGKTAMSDQD
IFNAYIHDYPTEIIQIPCAYNYQLGALTKSKELCPETPLALHFNSQNKTVGKNYAFFDKI
RKAFDEMDGSDLKRRRRSFKGNNQKDICHEYLPLDNFRIIPNAIGRMTKPAELCMVTQFS
KDRLNHFLESANAWRHPISTAVYGKDKDLLDIAKAVTELNRTDITIHLVFEEPTESWMLD
SLYPINFLRNVAIEHANCKYILMTDVDFVVLGDYGTIIDQTGNLKQKEVLVIPALEMTYP
QLRLNLSNFLSRKDLVIEHLLNKTIQTFRETIWPSSHVPTNISKWIKSNRTYMVNYEKNY
EPYFVIKKEECPFYDQRFGGFGWNKVTHVMQLKMMNYKFLVSPTSFMIHQNHNASKSLKR
WRRDPHYQKCLHTLKNKFMKKTASRLGIKLR
|
| References |
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
| Functional Descriptions |
lge-1
|
| Deletion Mutants |
tm1051
|
| In Situ |
|
| Expression |
Expression
| db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
| WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
| WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00031532 : Larva_Pan_Neuronal_Enriched
|
WBPaper00031532
|
WormAtlas
|
| WB |
WBbt:0005813
|
body wall musculature |
"Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] |
Enriched |
WBPaper00040985 : AIN-2_asynchronous_muscle
|
WBPaper00040985
|
WormAtlas
|
|
WBGene00010716
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
|
linker cell migration variant
|
"Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control." [WB:WBPaper00028966, WB:WBPerson2021]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
