JCEG ID JCEG124
Name gsy-1      WormBase    NCBI Gene
Human Ortholog

GGDB:GYS1 GYS2 

OMIM: 138570 138571 240600 611556

OrthoList :   GYS1   GYS2  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.08 0.00000004 (FSH) 24049095
Family Name Glycogen synthase
Locus Tag Y46G5A.31
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.

Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.

Barberan-Soler S, Zahler AM PLoS Genet. (2008) 4 (2) :e1000001 [PMID : 18454200] Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.

Frazier HN, Roth MB Curr. Biol. (2009) 19 (10) :859-63 [PMID : 19398339] Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

LeGendre JB, Campbell ZT, Kroll-Conner P, Anderson P, Kimble J, Wickens M J. Biol. Chem. (2012) 288 (4) :2532-45 [PMID : 23195953] RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans.

WormBase (WS254)

Functional Descriptions gsy-1

gsy-1 is orthologous to the human gene GLYCOGEN SYNTHASE 1 (GYS1; OMIM:138570); deficiencies of GYS1 may be associated with susceptibility to type 2 diabetes.
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003675

muscle cell "contractile cell that makes up muscle tissue." [WB:rynl] Enriched WBPaper00031003 : 24hr_muscle_enriched, total_muscle_enriched
WBPaper00031003 WormAtlas
WB WBbt:0005270

DD neuron "Neuron class of six motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. Each cell has a short, posteriorly directed and a longer, anteriorly directed process emanating from its cell body. The anterior process has a branch, which leaves the ventral cord as a commissure and runs round to the dorsal cord." [WB:Paper00000938] Enriched WBPaper00048563 : L1_DD_enriched
WBPaper00048563
WB WBbt:0006849

germline precursor cell "member of a set of two cells that generate exclusively sperm and ovum." [WB:rynl] Enriched WBPaper00037950 : germline-precursors_embryo_enriched
WBPaper00037950

WBGene00001793
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
anoxia hypersensitive

"Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021]
RNAi: WBRNAi00080787   WBPaper00033086   Observed
cortical dynamics defective early emb

"Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141]
RNAi: WBRNAi00056690   WBPaper00025054   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00009339   WBPaper00005654   Observed
RNAi: WBRNAi00056690   WBPaper00025054   Observed
glycogen levels variant

"Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987]
RNAi: WBRNAi00080786   WBPaper00033086   Observed
larval lethal

"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
RNAi: WBRNAi00009339   WBPaper00005654   Observed
locomotion variant

"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
RNAi: WBRNAi00009339   WBPaper00005654   Observed
organism high sodium chloride hypersensitive

"Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab]
RNAi: WBRNAi00106214   WBPaper00048631   Observed
organism morphology variant

"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
RNAi: WBRNAi00009339   WBPaper00005654   Observed
slow embryonic development

"The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712]
RNAi: WBRNAi00106627   WBPaper00046953   Observed


Top




Insert title here