JCEG ID |
JCEG093 |
Name |
glct-3
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:B3GAT1
OMIM:
151290
245600
606374
607497
OrthoList :
B3GAT3
B3GAT2
B3GAT1
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Glucuronyltransferase(GlcAT) |
Locus Tag |
T15D6.7
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
tm:soluble
dxd:DDD
gg_motif:M1, M2, M3, M4
|
Sequence |
CDS
atgtcgaatagactcgggggttttgcaatacgttggtatgctgttggagg attgtttggaggttcagagatcgtatcgagtatattgaaagacgaccccc gaatcttgaatttcatagtcacatacgcttttagaatcaaaccaacttct cctcaggactctggttcaaatcgaatgataattgtaatcacgcctactta caaaagaattactaggttggctgatataacacgattggctaacacattgt ctcaagtcgaaaatttgcattggatcgtaatagaggatggagagtcaact attcctaatgttcaaaatattttggaacggtctgagctactgtataccta tgtagcgcaccgaactgcttcaggataccctgcccgaggatggtaccagc gagatatggcattaaagttgatacggacaaacccatcccaaatcctgggt gagcatgagggagaagctgtgatttattttgcagacgatgataattctta cgacttgcgactatttgaggattatatcaggaatgtgaagaagctgggtc tttgggctgttggcttggctggtggagcagcagtggaggctccaaacgta gtgaacaagaaagtcacttcattcaatttcaagtggaaatccaagcgacg attcgctgttgatatggcgggatttgcaatcaatcttgactatatcctaa attccagtgcagtgttcggtacggaatgtaagagaggtgatggcgctccg gagacttgtctcctcgaggatctaggtttcgatttgaatgatattgaacc ttttgggtatgagaaagagaaaaacaatgagatcttggtatggcacacta aaactagttattcgggcatgaaggtcaaggaagcggaaaaatttggatat tttgtggaaccataa
|
Protein
MSNRLGGFAIRWYAVGGLFGGSEIVSSILKDDPRILNFIVTYAFRIKPTSPQDSGSNRMI IVITPTYKRITRLADITRLANTLSQVENLHWIVIEDGESTIPNVQNILERSELLYTYVAH RTASGYPARGWYQRDMALKLIRTNPSQILGEHEGEAVIYFADDDNSYDLRLFEDYIRNVK KLGLWAVGLAGGAAVEAPNVVNKKVTSFNFKWKSKRRFAVDMAGFAINLDYILNSSAVFG TECKRGDGAPETCLLEDLGFDLNDIEPFGYEKEKNNEILVWHTKTSYSGMKVKEAEKFGY FVEP
|
References |
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
glct-3
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
|
WBGene00011781
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|