JCEG ID | JCEG089 | ||||||||
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Name | cgt-2 WormBase NCBI Gene | ||||||||
Human Ortholog |
GGDB:UGCG OMIM: 602874 OrthoList : UGCG (Ensembl Compara)
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Family Name | GlcT | ||||||||
Locus Tag | F20B4.6 | ||||||||
RNAi phenotype |
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Sequence Features |
tm:soluble gg_motif:M1, M2, M3, M4, M5, M6 |
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Sequence | CDS |
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Protein |
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References |
Ichikawa S, Hirabayashi Y Trends Cell Biol. (1998) 8 (5) :198-202 [PMID : 9695839] Glucosylceramide synthase and glycosphingolipid synthesis. Leipelt M, Warnecke D, Zahringer U, Ott C, Muller F, Hube B, Heinz E J. Biol. Chem. (2001) 276 (36) :33621-9 [PMID : 11443131] Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi. Lochnit G, Bongaarts R, Geyer R Int. J. Parasitol. (2005) 35 (8) :911-23 [PMID : 15885697] Searching new targets for anthelminthic strategies: Interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Marza E, Simonsen KT, Faergeman NJ, Lesa GM J. Cell. Sci. (2009) 122 (Pt 6) :822-33 [PMID : 19240113] Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. Nomura KH, Murata D, Hayashi Y, Dejima K, Mizuguchi S, Kage-Nakadai E, Gengyo-Ando K, Mitani S, Hirabayashi Y, Ito M, Nomura K Glycobiology (2011) 21 (6) :834-48 [PMID : 21325339] Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
Functional Descriptions |
cgt-2 cgt-2 encodes a transmembrane protein that is one of three C. elegans ceramide glucosyltransferases; by homology, CGT-2 is predicted to localize to the Golgi membrane and catalyze the transfer of glucose from UDP-glucose to ceramide to synthesize glucosylceramide, a glycosphingolipid precursor; although cgt-2 mutant worms show no obvious defects, cgt-3;cgt-1;cgt-2 triply mutant animals show reduced glucosylceramide levels; expression of cgt-2 in Saccharomyces cerevisiae results in de novo biosynthesis of glucosylceramides, absent from the parental strain. |
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Deletion Mutants | tm1097 tm1192 | |||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||
Expression |
Expression
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WBGene00017625 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||
reduced brood size
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"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557] |
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