| JCEG ID |
JCEG087 |
| Name |
ZC250.2
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:B3GLCT
OMIM:
261540
610308
OrthoList :
B3GLCT
(Ensembl Compara)
GWAS Catalog
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.44 |
0.00000002
|
1.1
|
|
[1.07-1.14] |
23455636
|
|
Fritsche LG 2013-03-03 Nat Genet
Seven new loci associated with age-related macular degeneration.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
GlcT |
| Locus Tag |
ZC250.2
|
| RNAi phenotype |
|
phenotype
|
WT
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
|
|
hsp-4::GFP (Image)
|
|
|
| Sequence Features |
dxd:DDD
tm:soluble
|
| Sequence |
CDS
atgcaactattaatcatcttatctatattgttgtcactatgtgatacgga
gaatttgacggttttattagttggatctagatacaaacttactgaacaaa
gagtaatggaaaggaggaagcaaattttagcagattgtgaaatattaaag
ctctcttgttccgttttcgacgctctaaatgatttttccacggaatctta
tcctcaagggatgtggactatagttcccgcaattatgaaattgccgttta
tttctgattggataatcatcgcagaagatacttctgaaattaatatttca
aacttaccgaagttcttcgaatctgaaccatcttctgatatggtattttc
cgggtttgcacttcaggatcgagacccgacaattatccatcactttggaa
tgaatgctcctgaaaatttccaatatcccttattttctgctggttttatc
ttgtcaaaaagtgtagttgaaattattcgaaaagtcgatataaacgatcg
atggtccggatttgcaattgatgcaaaatatgagtttgctcagtttttac
acaaatgggaaaatttgaggcttcaccatcatcctgattatttttgttgt
ggagataccattgatagttgcattgtaaaatgttcaattccctttccaaa
aacgtcaaattcaatttctgattctgaagttcatgtcatggtcaaaacgt
tcgaaggacatcatgtgaaccgacttgaagttctcaaaaacacttgggca
tccgacgtgtcacgcatagagtactgtagcgacaaagaggatccggcaat
tccaacaatcaatctaggagtcgacaatacggacagaggacattgtgcaa
agacatgggaaatattcagaagatttttgggaagttctggaaatggagcg
aaatggcttgtagtagccgatgatgatacattgatgaatttcaaacggtt
gaagcaaatgttagagttatatgattctggagataagataattattggcg
agcgctatggatatggatttagtttgaatggtgacagtggatatgactat
cccactggcggatctggaatgatattcacgcgctccgcagttgaatcttt
acttgcacaatgcccatcgtgtattgcaaatactgatccggatgatatga
cgatcggaatttgtgcactaacagctggaattccaattgttcacgaatct
agattacatcaagcgagacctctagattatgctccggagtacataaaata
tccaatatcatttcataaatttactgatatagatccaatttcagtatatt
acgagtacctagtagaattagaagaatataatcacaaatctgagctttag
|
Protein
MQLLIILSILLSLCDTENLTVLLVGSRYKLTEQRVMERRKQILADCEILKLSCSVFDALN
DFSTESYPQGMWTIVPAIMKLPFISDWIIIAEDTSEINISNLPKFFESEPSSDMVFSGFA
LQDRDPTIIHHFGMNAPENFQYPLFSAGFILSKSVVEIIRKVDINDRWSGFAIDAKYEFA
QFLHKWENLRLHHHPDYFCCGDTIDSCIVKCSIPFPKTSNSISDSEVHVMVKTFEGHHVN
RLEVLKNTWASDVSRIEYCSDKEDPAIPTINLGVDNTDRGHCAKTWEIFRRFLGSSGNGA
KWLVVADDDTLMNFKRLKQMLELYDSGDKIIIGERYGYGFSLNGDSGYDYPTGGSGMIFT
RSAVESLLAQCPSCIANTDPDDMTIGICALTAGIPIVHESRLHQARPLDYAPEYIKYPIS
FHKFTDIDPISVYYEYLVELEEYNHKSEL
|
| References |
|
| Functional Descriptions |
ZC250.2
none available
|
| Deletion Mutants |
tm2958
tm3017
|
| In Situ |
|
| Expression |
Expression
|
WBGene00022576
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|