JCEG ID JCEG070
Name Y54E10BR.1      WormBase    NCBI Gene
Human Ortholog

GGDB:PIGN 

OMIM: 606097 614080

OrthoList :   PIGN  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.000009 (phenotype 3) 3.57 [NR] 25461247
MAPPED 0.000009 (phenotype 1) 3.57 [NR] 25461247
Family Name GPI-anchor synthesis
Locus Tag Y54E10BR.1
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Maeda I, Kohara Y, Yamamoto M, Sugimoto A Curr. Biol. (2001) 11 (3) :171-6 [PMID : 11231151] Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi.

Severson AF, Baillie DL, Bowerman B Curr. Biol. (2002) 12 (24) :2066-75 [PMID : 12498681] A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.

Sawa M, Suetsugu S, Sugimoto A, Miki H, Yamamoto M, Takenawa T J. Cell. Sci. (2003) 116 (Pt 8) :1505-18 [PMID : 12640035] Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure.

Ackerman D, Gems D PLoS Genet. (2012) 8 (3) :e1002498 [PMID : 22396654] Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.

WormBase (WS254)

Functional Descriptions Y54E10BR.1

none available
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003675

muscle cell "contractile cell that makes up muscle tissue." [WB:rynl] Enriched WBPaper00031003 : 0hr_muscle_enriched, total_muscle_enriched
WBPaper00031003 WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_enriched
WBPaper00037950 WormAtlas

WBGene00021840
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
actin cytoskeleton filament morphology variant

"Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00083310   WBPaper00005843   Observed
avoids bacterial lawn

"Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021]
RNAi: WBRNAi00095800   WBPaper00040984   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00001430   WBPaper00004651   Observed
RNAi: WBRNAi00022833   WBPaper00005603   Observed
RNAi: WBRNAi00083294   WBPaper00005843   Observed
epithelial morphology variant

"Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00083301   WBPaper00005843   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00001430   WBPaper00004651   Observed
sick

"Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
RNAi: WBRNAi00001430   WBPaper00004651   Observed
transgene expression increased

"Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
RNAi: WBRNAi00092045   WBPaper00040863   Observed
RNAi: WBRNAi00095914   WBPaper00040984   Observed
RNAi: WBRNAi00096297   WBPaper00040984   Observed
ventral closure defective

"The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712]
RNAi: WBRNAi00083301   WBPaper00005843   Observed


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