JCEG ID JCEG065
Name T27F7.4      WormBase    NCBI Gene
Human Ortholog

GGDB:PIGB 

OMIM: 604122

OrthoList :   PIGB  (Ensembl Compara)

GGDB Score E-val
ALG9 55 3e-09
ALG12 51 4e-08
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name GPI-anchor synthesis
Locus Tag T27F7.4
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.

Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH PLoS Biol. (2003) 1 (1) :E12 [PMID : 14551910] Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.

Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M Genome Res. (2004) 14 (10B) :2162-8 [PMID : 15489339] Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.

Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.

Curran SP, Ruvkun G PLoS Genet. (2007) 3 (4) :e56 [PMID : 17411345] Lifespan regulation by evolutionarily conserved genes essential for viability.

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK PLoS Genet. (2010) 6 (8) [PMID : 20700440] RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK PLoS Genet. (2011) 7 (6) :e1002119 [PMID : 21695230] Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

WormBase (WS254)

Functional Descriptions T27F7.4

none available
Deletion Mutants
In Situ
Expression Expression

Phenotype
WBGene00194986
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
apoptosis reduced

"Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
cell membrane organization biogenesis variant

"Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
cytoplasmic processing body variant

"Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712]
RNAi: WBRNAi00094043   WBPaper00040559   Observed
diakinesis region organization variant

"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
diplotene region organization variant

"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
dumpy

"Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497]
RNAi: WBRNAi00026423   WBPaper00006395   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00009230   WBPaper00005654   Observed
extended life span

"The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712]
RNAi: WBRNAi00066169   WBPaper00029254   Observed
RNAi: WBRNAi00088474   WBPaper00036765   Observed
RNAi: WBRNAi00088479   WBPaper00036765   Observed
RNAi: WBRNAi00088484   WBPaper00036765   Observed
RNAi: WBRNAi00088488   WBPaper00036765   Observed
RNAi: WBRNAi00088498   WBPaper00036765   Observed
germ cell compartment expansion variant

"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
germ cell compartment morphology variant

"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
germ cell compartment multinucleate

"Germ cell compartments contain multiple nuclei." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
germline nuclear positioning variant

"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
gonad degenerate

"Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
gonad migration variant

"Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
gonad morphology variant

"Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
gonad vesiculated

"Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00026423   WBPaper00006395   Observed
RNAi: WBRNAi00036053   WBPaper00024497   Observed
RNAi: WBRNAi00066252   WBPaper00029254   Observed
RNAi: WBRNAi00094043   WBPaper00040559   Observed
larval lethal

"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
RNAi: WBRNAi00036053   WBPaper00024497   Observed
life span variant

"Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557]
RNAi: WBRNAi00066252   WBPaper00029254   Observed
locomotion variant

"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
RNAi: WBRNAi00009230   WBPaper00005654   Observed
maternal sterile

" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
RNAi: WBRNAi00036053   WBPaper00024497   Observed
RNAi: WBRNAi00054349   WBPaper00025054   Observed
mRNA levels increased

"Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
RNAi: WBRNAi00088467   WBPaper00036765   Observed
RNAi: WBRNAi00089298   WBPaper00039783   Observed
mRNA levels reduced

"Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
RNAi: WBRNAi00088467   WBPaper00036765   Observed
RNAi: WBRNAi00088469   WBPaper00036765   Observed
RNAi: WBRNAi00089474   WBPaper00039783   Observed
mRNA surveillance defective

"Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926]
RNAi: WBRNAi00094313   WBPaper00040559   Observed
RNAi: WBRNAi00094429   WBPaper00040559   Observed
nonsense mRNA accumulation

"Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00094313   WBPaper00040559   Observed
nuclear fallout

"Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
oocyte morphology variant

"Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
oocyte number decreased

"A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
oocytes small

"The size of haploid female germ cells (oocytes) are significantly smaller compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
organism oxidative stress resistant

"Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals." [WB:WBPerson2021]
RNAi: WBRNAi00088373   WBPaper00036765   Observed
RNAi: WBRNAi00088427   WBPaper00036765   Observed
RNAi: WBRNAi00088447   WBPaper00036765   Observed
pachytene region organization variant

"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
patchy coloration

"Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00009230   WBPaper00005654   Observed
protein expression reduced

"Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva]
RNAi: WBRNAi00089482   WBPaper00039783   Observed
protein phosphorylation increased

"Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021]
RNAi: WBRNAi00089323   WBPaper00039783   Observed
rachis morphology variant

"Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
rachis narrow

"The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085581   WBPaper00038381   Observed
shortened life span

"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
RNAi: WBRNAi00088492   WBPaper00036765   Observed
RNAi: WBRNAi00088501   WBPaper00036765   Observed
slow growth

"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
RNAi: WBRNAi00009230   WBPaper00005654   Observed
RNAi: WBRNAi00096911   WBPaper00041034   Observed
sterile progeny

"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00009230   WBPaper00005654   Observed
transgene expression increased

"Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
RNAi: WBRNAi00088035   WBPaper00036765   Observed
RNAi: WBRNAi00088250   WBPaper00036765   Observed
RNAi: WBRNAi00088332   WBPaper00036765   Observed
RNAi: WBRNAi00094313   WBPaper00040559   Observed
RNAi: WBRNAi00094429   WBPaper00040559   Observed
RNAi: WBRNAi00096911   WBPaper00041034   Observed
RNAi: WBRNAi00096971   WBPaper00041034   Observed
transgene expression variant

"Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557]
RNAi: WBRNAi00066229   WBPaper00029254   Observed
transgene subcellular localization variant

"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
RNAi: WBRNAi00066301   WBPaper00029254   Observed
RNAi: WBRNAi00094043   WBPaper00040559   Observed
RNAi: WBRNAi00094234   WBPaper00040559   Observed


Top




Insert title here