| JCEG ID |
JCEG020 |
| Name |
F56H6.1
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:C1GALT1
OMIM:
OrthoList :
C1GALT1C1
(Ensembl Compara)
GWAS Catalog
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
Core 1 GalT |
| Locus Tag |
F56H6.1
|
| RNAi phenotype |
|
phenotype
|
WT
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
Normal
|
|
hsp-4::GFP (Image)
|
|
|
| Sequence Features |
tm:soluble
dxd:DDD
gg_motif:M1,M3,M4,M6
|
| Sequence |
CDS
atggctgccacttttgagcgtttggaccaggtagcacttcttgcacttgt
aacagttgccgctttgaattatcagatttttacctatcaacggaagtttt
taatgcctgccgagctctacacatatttccccgccatgattcatcagaaa
ttttttcctccaactcggagcataggaaagctgaccccaggaattgtgca
ttcagcttctgccctagagcttccttccaccggacaactcttctgctttg
tggagacttccgcagtgcattatgatgaccgtgtaccatcaattgcgtct
acgtggcttccgaaatgtgacaacgggcggttcttcacaaaaactccact
tccaaactctaatatgacttattctacagtatatttaaacctgaaggact
cctactacgacttgttccgaaaaactacatttggattctattactcttat
atgcacatttcaaaatccttcgattggtacctaaaagctgatgacgatac
ttatttcgcaatggaccatttgaaggagtacctgagcacgctggatccta
caaagccactgtacttaggctatgttctgaaaccgtattttaaaaatggc
tacaactccggaggttccggctacatactatccaacgctgcagtgaaact
attcgtggagaagctgtatcacgacgagtacacatgcccctacgattggg
cagaggatcgtggaatgggcagatgcatggctcgagccgggattttcccg
actgataccagagatgataaagggctgaatcgattcatgccgttcaagcc
cagtgagctcgccggagttgggcctgaatggcattattatccgatggagg
ccggtcaatatgcatcacagaagttcgtttcccttcaccgcctccctcag
gacatgatgatctccctcgacgatattctccacccaaagctgggcaaacg
tgtatataatccgaaatttgtgaaacttgattag
|
Protein
MAATFERLDQVALLALVTVAALNYQIFTYQRKFLMPAELYTYFPAMIHQKFFPPTRSIGK
LTPGIVHSASALELPSTGQLFCFVETSAVHYDDRVPSIASTWLPKCDNGRFFTKTPLPNS
NMTYSTVYLNLKDSYYDLFRKTTFGFYYSYMHISKSFDWYLKADDDTYFAMDHLKEYLST
LDPTKPLYLGYVLKPYFKNGYNSGGSGYILSNAAVKLFVEKLYHDEYTCPYDWAEDRGMG
RCMARAGIFPTDTRDDKGLNRFMPFKPSELAGVGPEWHYYPMEAGQYASQKFVSLHRLPQ
DMMISLDDILHPKLGKRVYNPKFVKLD
|
| References |
|
| Functional Descriptions |
F56H6.1
none available
|
| Deletion Mutants |
|
| In Situ |
|
| Expression |
Expression
|
WBGene00010162
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|