| JCEG ID |
JCEG014 |
| Name |
algn-13
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:ALG13
OMIM:
OrthoList :
| GGDB |
Score |
E-val |
|
ALG13
|
120 |
1e-29 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
Asparagine-linked glycosylation (ALG) genes |
| Locus Tag |
R10D12.12
|
| RNAi phenotype |
|
phenotype
|
hsp-4::GFP increase
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
Increase
|
|
hsp-4::GFP (Image)
|
Increase
|
|
| Sequence Features |
tm:soluble
|
| Sequence |
CDS
atgagttgcttcgtgacggttggatcaacattgttcgaagacttgataaa
tcaagttctttgtgaagcatcactagaaaatctcaaaaagatcggagtca
agaagattcgccttcaaattggaaaaggaaatttcaatcaagacgtcatt
gatcgtgtttttggagaaacatctggagatgaaggatctgtaaagtgtga
tggtctcgatatagattattatcgttacaagccatcgttgagtgaagata
tggctgaagctttgattgtaattggccacggaggtgccggaacttgcttg
gaagtgttggcgcttcatctcccattcatcacagtaacaaacgataaact
aatggacaatcatcaagccgaactcgccgtgcaactttcagacgaaggat
accttctccaatgcaccccatcaacgcttccagaaactattttgaaagaa
aatttgttctctcttagacaatttgcagcgccttcaaagaagtttgtcgc
tgaacatatcaaacaattggttggaatcaagaatcattaa
|
Protein
MSCFVTVGSTLFEDLINQVLCEASLENLKKIGVKKIRLQIGKGNFNQDVIDRVFGETSGD
EGSVKCDGLDIDYYRYKPSLSEDMAEALIVIGHGGAGTCLEVLALHLPFITVTNDKLMDN
HQAELAVQLSDEGYLLQCTPSTLPETILKENLFSLRQFAAPSKKFVAEHIKQLVGIKNH
|
| References |
Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV
PLoS Pathog.
(2011)
7
(3)
:e1001314
[PMID : 21408619]
Global functional analyses of cellular responses to pore-forming toxins.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
Winter JF, Hopfner S, Korn K, Farnung BO, Bradshaw CR, Marsico G, Volkmer M, Habermann B, Zerial M
Nat. Cell Biol.
(2012)
14
(7)
:666-76
[PMID : 22634595]
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.
|
| Functional Descriptions |
algn-13
|
| Deletion Mutants |
|
| In Situ |
In Situ
|
| Expression |
Expression
| db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
| WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
|
WBGene00011193
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
Bacillus thuringiensis toxin hypersensitive
|
"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
|
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
pore forming toxin hypersensitive
|
"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
RAB-11 recycling endosome localization variant
|
"Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
|
|
RAB-11 recycling endosome morphology variant
|
"Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
transgene subcellular localization variant
|
"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
