JCEG ID |
JCEG011 |
Name |
tag-179
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:ALG10
OMIM:
603313
OrthoList :
ALG10B
ALG10
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
|
0.000008
(WRAT)
|
|
|
|
17903297
|
|
Seshadri S 2007-09-19 BMC Med Genet
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
|
GGDB |
Score |
E-val |
ALG10
|
161 |
2e-41 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Asparagine-linked glycosylation (ALG) genes |
Locus Tag |
T24D1.4
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
Normal
|
|
Sequence Features |
tm:Detected
kr:N.D.
|
Sequence |
CDS
atgacaaaatcgaaaccgccccgaataagcctgccatttgccgcaatatc caggaaaagcgattttctacttggtgcttcgttttcttgcattcacgttc tgctgacaacaattgtctaccactatgttccagagccgtatatggatgag atcttccacattactcaaactagatcatattgctcaggaaattacagctg gaatccattaattacaactccaccggcactttatgttatttcaatgccat tatgtggtggaaatgaaagatacgctaactcgattcttctatttttcgct ataccagcattttgccgttttcggagaatgttcgttagacaagatgtatg gctgactgcatcaatcgtcggaatgcttccaattttgatatcgtcttcaa ttcttttttataccgatttgttgtcactcacttcagttatttggggattt tcgatcggaaacccaattgcatctgcgttcttattcctaatctcaatact gacacgccagacaaatatcatttgggcagcgatatacgcgttctctgtaa ttgcttcaagaattgacaagtcccgctcaaaaatggaaaatcttaagatc ataatttcaactgcattttctctatggccattcattacacttgcaattgg atttgcgatgtttatatatttcaatgatttccaaattgtccttggagatg caaaagctcaccaaccaaagttccacgtggctcaatttttctacatggtt gcattctgcgcggctcacacttggactcaaatcatcccaaatctgttatc tcaccttcgacacctaaccgacatgaaatcattagttctacaagcagttg tggcagttcttgtctactactattcttatgatcacccgtatcttctcgct gataatcggcatttcacattctacatctggaggcgattcttggcaaatcc cacaatgcggacaactcttgctcctctctacgtgttttctttaagattta tgacgacatcgacaccgtccgtgcatatattccacaaaattctatttata atcgcatctttactcgttttggttccagctcatctattcgaaatgcgata ttatattattccttatgttctctggagactttcgactgtaaataactcta gaaaatcacttctcttcttggaaattatatctcaagctgtgatttttgcg gcagtttttgttttattcttatttaaaacgttcgaatggtccaacgaacc tggcgtcaagcaacggttcatgttctag
|
Protein
MTKSKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHYVPEPYMDEIFHITQTRSY CSGNYSWNPLITTPPALYVISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRQDVWLTA SIVGMLPILISSSILFYTDLLSLTSVIWGFSIGNPIASAFLFLISILTRQTNIIWAAIYA FSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIGFAMFIYFNDFQIVLGDAKAHQPK FHVAQFFYMVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLA DNRHFTFYIWRRFLANPTMRTTLAPLYVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPA HLFEMRYYIIPYVLWRLSTVNNSRKSLLFLEIISQAVIFAAVFVLFLFKTFEWSNEPGVK QRFMF
|
References |
Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR
Proc. Natl. Acad. Sci. U.S.A.
(2004)
101
(32)
:11773-8
[PMID : 15280551]
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
tag-179
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
|
WBGene00007043
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
locomotion variant
|
"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
pharyngeal pumping rate variant
|
"The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|