| JCEG ID |
JCEG001 |
| Name |
algn-1
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:ALG1
OMIM:
605907
608540
OrthoList :
ALG1
ALG1L
ENSG00000225547
ALG1L8P
ALG1L5P
(Ensembl Compara)
| GGDB |
Score |
E-val |
|
ALG1
|
324 |
2e-90 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
Asparagine-linked glycosylation (ALG) genes |
| Locus Tag |
T26A5.4
|
| RNAi phenotype |
|
phenotype
|
Emb
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
Normal
X axis; time of flight (length of each organism) Y axix; intensity
|
|
hsp-4::GFP (Image)
|
Normal
|
|
| Sequence Features |
tm:Detected
kr:Detected
|
| Sequence |
CDS
atggcaaaggaagacgacgaatcgccagacgagagaagtgaagccgcagt
cgtcgttcttggtgatgtcggcagaagcccacgaatgtgtaatcacgcaa
aaatgctcgctgatgaaggatttgatgtcaaacttattggatttttcgat
tctattccaggagaacaaattatgaatcatccaaggataaaaatagttgg
aatcccgccacctcctgacttcatggattcgttaccagctttcgtgcaac
ttccactgaaacttttttggaactttataactcttttcttggctctcgct
tttcaaacaagcgcctttaatttaagaattattcttatgcagaatccgcc
ggcgcttccgacgatgatagtttgtttcatgttttccatattcaaattcg
caaaattctcaattgattggcacaattacatgtattcaattctacaaaat
aaataccaattgaccgatgatcaagtttttggaaacgataaaaaaaccaa
aaaagcccaaattgtgagatgtgttggattcctagaaggtctatgtggaa
aactatccgattataatctgtgtgtaacaaatgccatgcgtcgagatctc
atggatcgatggggcatcagagccagcacattctatgataggccgccgac
gtggaaatttagagacacaacaatacaagagatccatgatttgtatctaa
gactttcacaaaaggaacgaattctacaaggaaaagacgaagactccaca
attctgactcataaatcttcgaacggagtagtgcagctactaacaactcg
acccattgtgtttctctcttccacatcctggacacctgatgaacggtttg
aaattcttctcgatgcgctggttgcatatgacaaaacaatcggactcccg
cgagttttgatgattatcactggaaaaggtccactgaaagcgaaatattt
acaagaaattcacgagaaaaatctgaagaatgtcgatgtattgactccat
ggttggaagcagaagattatccaaagattctagcctctgctgacttagga
atctctttgcacacaagcacgtctggattggatcttccgatgaaagttgt
tgatatgtttggagctaaagttccagcattggctctaaaattcaaatgta
ttgatgagctcgttgaggagaaaactaatggatatcttttcgatgattct
gagcagttgagtcgtcaaattattgaactttctcgtggattcccaaataa
ttgcaatgaattgatacggctcaagaagaatacacaggagcaaaaattcg
attcttgggaagtgatgtggaagagatcagctacctctggtgcagacttt
cgagttccagacaatggattcgccaaacttcgtgcaattattcaattctc
atttttcgctattttattgatcatgccgattcacttatttatgggcactt
tttcgggggcattcagatcgctttaa
|
Protein
MAKEDDESPDERSEAAVVVLGDVGRSPRMCNHAKMLADEGFDVKLIGFFDSIPGEQIMNH
PRIKIVGIPPPPDFMDSLPAFVQLPLKLFWNFITLFLALAFQTSAFNLRIILMQNPPALP
TMIVCFMFSIFKFAKFSIDWHNYMYSILQNKYQLTDDQVFGNDKKTKKAQIVRCVGFLEG
LCGKLSDYNLCVTNAMRRDLMDRWGIRASTFYDRPPTWKFRDTTIQEIHDLYLRLSQKER
ILQGKDEDSTILTHKSSNGVVQLLTTRPIVFLSSTSWTPDERFEILLDALVAYDKTIGLP
RVLMIITGKGPLKAKYLQEIHEKNLKNVDVLTPWLEAEDYPKILASADLGISLHTSTSGL
DLPMKVVDMFGAKVPALALKFKCIDELVEEKTNGYLFDDSEQLSRQIIELSRGFPNNCNE
LIRLKKNTQEQKFDSWEVMWKRSATSGADFRVPDNGFAKLRAIIQFSFFAILLIMPIHLF
MGTFSGAFRSL
|
| References |
Fernandez AG, Gunsalus KC, Huang J, Chuang LS, Ying N, Liang HL, Tang C, Schetter AJ, Zegar C, Rual JF, Hill DE, Reinke V, Vidal M, Piano F
Genome Res.
(2005)
15
(2)
:250-9
[PMID : 15687288]
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones.
Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG
Nat. Genet.
(2006)
38
(8)
:896-903
[PMID : 16845399]
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
|
| Functional Descriptions |
algn-1
|
| Deletion Mutants |
|
| In Situ |
In Situ
|
| Expression |
Expression
|
WBGene00020820
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
embryonic development variant
|
"Variations in the progression of an embryo over time, from zygote formation to hatching compared to control." [GO:0009790, WB:WBPerson2021]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
organism UV hypersensitive
|
"Organisms respond to UV at a lower dose or a shorter exposure compared to control animals." [WB:WBPerson557]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
|
protein aggregation variant
|
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile
|
"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
transgene subcellular localization variant
|
"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
