Reaction:JCGG-RAC0002850

JCGG ID		JCGG-RAC0002850
Submitter		The Noguchi Institute
Reaction ID		R-0000-002850
Regist Date		2012/06/21 19:58:10
REACTANT
MOLECULE ID		JCGG-COM0003736 (Reaction Tree)
	Reactant Type	donor
	Mol	0.21 mmol
MOLECULE ID		JCGG-COM0003737 (Reaction Tree)
	Reactant Type	acceptor
	Mol	0.23 mmol
MOLECULE ID		JCGG-COM0001843
	Reactant Type	Cp2ZrCl2
	Mol	0.41 mmol
MOLECULE ID		JCGG-COM0000032
	Reactant Type	AgClO4
	Mol	0.82 mmol
PRODUCT
MOLECULE ID		JCGG-COM0003738 (Reaction Tree)
	Product Type	alpha
	Yield	85%(alpha/beta=1/49)
MOLECULE ID		JCGG-COM0003739 (Reaction Tree)
	Product Type	beta
	Yield	85%(alpha/beta=1/49)
REACTION DETAIL
Reaction Time		30 minutes, 1 hour, 2.5 hours
Reaction Temp		room temp, -60 degree C, -50 degree C
Solvent		anhydrous CH2Cl2 (4.6mL), anhydrous CH2Cl2 (4.6+5mL), anhydrous CH2Cl2 (4.6+5mL)
Comment		1) Cp2ZrCl2+AgClO4, MS 4A, 2) +donor, acceptor, 3) temperature change
		MS 4A was included in the solvent.
COMMENT
Keywords: Biantennary, N-glycans, LacNAc, LacdiNAc, SPPS
There are multiple phases in this reaction.
REFERENCE
Reference Id		REF-0000-000371
	Issn	Electronic
	Doi	10.1021/jo200149d
	PubMed ID	21612260
	Journal Name	The Journal of organic chemistry. (2011) 76 (13): 5229-39.
	Article Title	Synthesis of biantennary complex-type nonasaccharyl asn building blocks for solid-phase glycopeptide synthesis.
	Author	Masashi, Hagiwara; Mizuki, Dohi; Yuko, Nakahara; Keiko, Komatsu; Yuya, Asahina; Akiharu, Ueki; Hironobu, Hojo; Yoshiaki, Nakahara; Yukishige, Ito
	Affiliation	Department of Applied Biochemistry, Institute of Glycoscience, Tokai University, 4-1-1 Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan.
Reference Id		REF-0000-000372
	Source	J. Org. Chem. 2011, 76, 5229-5239
	Doi	10.1021/jo200149d