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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002848 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002848
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Regist Date |
2012/06/21 19:57:43 | ||||
| REACTANT | |||||
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Reactant Type |
donor | ||||
Mol |
1.79 mmol | ||||
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Reactant Type |
acceptor (in 10 mL of anhydrous CH2Cl2) | ||||
Mol |
0.89 mmol | ||||
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Reactant Type |
BSP | ||||
Mol |
2.67 mmol | ||||
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Reactant Type |
TTBP | ||||
Mol |
3.58 mmol | ||||
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Reactant Type |
Tf2O | ||||
Mol |
1.98 mmol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
73% | ||||
| REACTION DETAIL | |||||
Reaction Time |
30 minutes, 20 minutes, 2 days | ||||
Reaction Temp |
-60 degree C, -60 degree C, -60 degree C | ||||
Solvent |
anhydrous CH2Cl2 (35mL), anhydrous CH2Cl2 (35mL), anhydrous CH2Cl2 (35mL) | ||||
Comment |
1) donor+BSP, TTBP, MS 4A, 2) +Tf2O, 3) +acceptor | ||||
| MS 4A was included in the solvent. | |||||
| COMMENT | |||||
| Keywords: Biantennary, N-glycans, LacNAc, LacdiNAc, SPPS | |||||
| There are multiple phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000371 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo200149d | ||||
PubMed ID |
21612260 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (13): 5229-39. | ||||
Article Title |
Synthesis of biantennary complex-type nonasaccharyl asn building blocks for solid-phase glycopeptide synthesis. | ||||
Author |
Masashi, Hagiwara; Mizuki, Dohi; Yuko, Nakahara; Keiko, Komatsu; Yuya, Asahina; Akiharu, Ueki; Hironobu, Hojo; Yoshiaki, Nakahara; Yukishige, Ito | ||||
Affiliation |
Department of Applied Biochemistry, Institute of Glycoscience, Tokai University, 4-1-1 Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan. | ||||
Reference Id |
REF-0000-000372 | ||||
Source |
J. Org. Chem. 2011, 76, 5229-5239 | ||||
Doi |
10.1021/jo200149d | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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