JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0002697
Submitter
The Noguchi Institute
Reaction ID
R-0000-002697
Regist Date
2012/06/21 19:39:36
REACTANT
MOLECULE ID
JCGG-COM0003519 (Reaction Tree)
Mol
2.09 mmol
MOLECULE ID
JCGG-COM0000979
Reactant Type
pyridine
Mol
20.9 mmol
MOLECULE ID
JCGG-COM0000838
Reactant Type
(ClAc)2O
Mol
6.3 mmol
PRODUCT
MOLECULE ID
JCGG-COM0003520 (Reaction Tree)
Yield
93%
REACTION DETAIL
Reaction Time
2.5 hours
Reaction Temp
ambient temperature
Solvent
CH2Cl2 (10mL)
Comment
The reactants were mixed at 0 degree in Celsius before stirred at ambient temperature.
COMMENT
Keywords: Streptococcus pneumonia, SP1, zwitterionic polysaccharide, ZPs, cis-glycosidic bond
REFERENCE
Reference Id
REF-0000-000363
Issn
Electronic
Doi
10.1021/jo102363d
PubMed ID
21341806
Journal Name
The Journal of organic chemistry. (2011) 76 (6): 1692-706.
Article Title
Galacturonic acid lactones in the synthesis of all trisaccharide repeating units of the zwitterionic polysaccharide Sp1.
Author
Alphert E, Christina; Leendert J, van den Bos; Herman S, Overkleeft; Gijsbert A, van der Marel; Jeroen D C, Codée
Affiliation
Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Reference Id
REF-0000-000364
Source
J. Org. Chem. 2011, 76, 1692-1706
Doi
10.1021/jo102363d

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)