JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0002666
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-002666
Regist Date
 2012/06/21 19:36:29
REACTANT
MOLECULE ID
 JCGG-COM0003472 (Reaction Tree)
Skeleton
JCGG-STR032526
Mol
 0.90 mmol
MOLECULE ID
 JCGG-COM0000408
Reactant Type
 PPh3
Mol
 1.86 mmol
MOLECULE ID
 JCGG-COM0000615
Reactant Type
 DIAD
Mol
 1.86 mmol
MOLECULE ID
 JCGG-COM0003473
Reactant Type
 DPPA
Mol
 1.86 mmol
PRODUCT
MOLECULE ID
 JCGG-COM0003474 (Reaction Tree)
Yield
 87%
REACTION DETAIL
Reaction Time
 overnight
Reaction Temp
 room temp
Solvent
 THF (20mL)
Comment
 The reactants were mixed at 0 degree in Celsius before stirred at room temperature.
COMMENT
Keywords: building block, ceramides, glycolipids, galactosyl-phytosphingosine, KRN7000
REFERENCE
Reference Id
 REF-0000-000361
Issn
 Electronic
Doi
 10.1021/jo102064p
PubMed ID
 21155575
Journal Name
 The Journal of organic chemistry. (2011) 76 (1): 320-3.
Article Title
 Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids.
Author
 Peter J, Jervis; Liam R, Cox; Gurdyal S, Besra
Affiliation
 School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Reference Id
 REF-0000-000362
Source
 J. Org. Chem. 2011, 76, 320-323
Doi
 10.1021/jo102064p
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)