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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002660 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002660
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Regist Date |
2012/06/21 19:35:53 | ||||
| REACTANT | |||||
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Mol |
28.8 mmol | ||||
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Reactant Type |
TBDMSOTf | ||||
Mol |
144.7 mmol | ||||
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Reactant Type |
2,6-lutidine | ||||
Volume |
50 mL | ||||
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Reactant Type |
MeOH | ||||
Volume |
100 mL | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
82% | ||||
| REACTION DETAIL | |||||
Reaction Time |
30 minutes, 20 hours, 10 minutes | ||||
Reaction Temp |
0 degree C, 25 degree C, 25 degree C | ||||
Solvent |
CH2Cl2 (400mL), CH2Cl2 (400mL), CH2Cl2 (400mL) | ||||
Comment |
1) 18+TBDMSOTf, 2,6-lutidine, 2) temperature change, 3) +MeOH | ||||
| COMMENT | |||||
| Keywords: building block, ceramides, glycolipids, galactosyl-phytosphingosine, KRN7000 | |||||
| There are multiple phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000361 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo102064p | ||||
PubMed ID |
21155575 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (1): 320-3. | ||||
Article Title |
Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids. | ||||
Author |
Peter J, Jervis; Liam R, Cox; Gurdyal S, Besra | ||||
Affiliation |
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. | ||||
Reference Id |
REF-0000-000362 | ||||
Source |
J. Org. Chem. 2011, 76, 320-323 | ||||
Doi |
10.1021/jo102064p | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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