JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0002601
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-002601
Regist Date
 2012/06/21 19:30:12
REACTANT
MOLECULE ID
 JCGG-COM0003376 (Reaction Tree)
Skeleton
JCGG-STR031569
Mol
 0.19 mmol
MOLECULE ID
 JCGG-COM0000345
Reactant Type
 BiCl3
Mol
 0.38 + 0.38 mmol
PRODUCT
MOLECULE ID
 JCGG-COM0003377 (Reaction Tree)
Skeleton
JCGG-STR031569
Yield
 75%
REACTION DETAIL
Reaction Time
 6 + 12 hours
Reaction Temp
 room temp
Solvent
 MeCN (10.0mL)
Comment
 BiCl3 was added twice. (0 hour, 6 hours)
COMMENT
Keywords: 2-methylchromone-7-O-rutinosides, cytotoxicity, human tumor cell lines, acidic labile, 2-methylchromone aglycon
The yield is 81% based on the recovery of the starting material.
REFERENCE
Reference Id
 REF-0000-000355
Issn
 Electronic
Doi
 10.1021/jo102325s
PubMed ID
 21366286
Journal Name
 The Journal of organic chemistry. (2011) 76 (7): 2265-8.
Article Title
 Concise synthesis of 5-methoxy-6-hydroxy-2-methylchromone-7-O- and 5-hydroxy-2-methylchromone-7-O-rutinosides. Investigation of their cytotoxic activities against several human tumor cell lines.
Author
 Baolin, Wu; Wenpeng, Zhang; Zhonghua, Li; Li, Gu; Xin, Wang; Peng George, Wang
Affiliation
 Department of Chemistry, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA.
Reference Id
 REF-0000-000356
Source
 J. Org. Chem. 2011, 76, 2265-2268
Doi
 10.1021/jo102325s
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)