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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002475 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002475
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Regist Date |
2012/06/21 19:17:46 | ||||
| REACTANT | |||||
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Mol |
0.077 mmol | ||||
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Reactant Type |
DIEA | ||||
Mol |
1.54 mmol | ||||
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Reactant Type |
MOMCl | ||||
Mol |
0.154 mmol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
81% | ||||
| REACTION DETAIL | |||||
Reaction Time |
overnight | ||||
Reaction Temp |
30 degree C | ||||
Solvent |
dry CH2Cl2 (1mL) | ||||
Comment |
The reactants were mixed at 0 degree in Celsius before stirred at 30 degree. | ||||
| All the reactants except MOMCl were mixed before the cooling. | |||||
| MOMCl was added dropwise. | |||||
| COMMENT | |||||
| Keywords: triazole, heparosan, chondroitin, copper catalyzed azide-alkyne cycloaddition, CuAAC, azido-glucuronic acid, glucosamine, galactosamine | |||||
| ATTENTION: DMAP appearing in the scheme is not mentioned in the written method. | |||||
| ATTENTION: There is a discrepancy between the scheme and the written method. (the reaction temperature) | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000343 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo200076z | ||||
PubMed ID |
21438620 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (9): 3181-93. | ||||
Article Title |
Design and synthesis of unnatural heparosan and chondroitin building blocks. | ||||
Author |
Smritilekha, Bera; Robert J, Linhardt | ||||
Affiliation |
Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA. | ||||
Reference Id |
REF-0000-000344 | ||||
Source |
J. Org. Chem. 2011, 76, 3181-3193 | ||||
Doi |
10.1021/jo200076z | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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