JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0002447
Submitter
The Noguchi Institute
Reaction ID
R-0000-002447
Regist Date
2012/06/21 19:15:03
REACTANT
MOLECULE ID
JCGG-COM0003180 (Reaction Tree)
Mol
3.18 mmol
MOLECULE ID
JCGG-COM0000506
Reactant Type
PhBCl2
Mol
5.09 mmol
MOLECULE ID
JCGG-COM0000507
Reactant Type
Et3SiH
Mol
4.45 mmol
PRODUCT
MOLECULE ID
JCGG-COM0003181 (Reaction Tree)
Yield
71%
REACTION DETAIL
Reaction Time
30 minutes
Reaction Temp
-78 degree C
Solvent
dry CH2Cl2 (30mL)
Comment
AW-300 was included in the solvent.
15 and AW-300 were mixed and stirred for 1 hour at room temperature before the reaction.
COMMENT
Keywords: triazole, heparosan, chondroitin, copper catalyzed azide-alkyne cycloaddition, CuAAC, azido-glucuronic acid, glucosamine, galactosamine
REFERENCE
Reference Id
REF-0000-000343
Issn
Electronic
Doi
10.1021/jo200076z
PubMed ID
21438620
Journal Name
The Journal of organic chemistry. (2011) 76 (9): 3181-93.
Article Title
Design and synthesis of unnatural heparosan and chondroitin building blocks.
Author
Smritilekha, Bera; Robert J, Linhardt
Affiliation
Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
Reference Id
REF-0000-000344
Source
J. Org. Chem. 2011, 76, 3181-3193
Doi
10.1021/jo200076z

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)