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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002148 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002148
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Regist Date |
2012/06/21 18:40:58 | ||||
| REACTANT | |||||
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Reactant Type |
intermediate | ||||
Mol |
0.02 mmol | ||||
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Reactant Type |
1H-tetrazole (0.45 M in MeCN) | ||||
Mol |
0.1 mmol | ||||
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Reactant Type |
(BnO)2PN(i-Pr)2 | ||||
Mol |
0.08 mmol | ||||
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Reactant Type |
MCPBA | ||||
Mol |
0.08 mmol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
95% | ||||
| REACTION DETAIL | |||||
Reaction Time |
2 hours, 3 hours, 1 hour | ||||
Reaction Temp |
room temp, room temp, room temp | ||||
Solvent |
CH2Cl2, CH2Cl2, CH2Cl2 | ||||
Comment |
1) 27+1H-tetrazole, MS 4A, 2) +(BnO)2PN(i-Pr)2, 3) +MCPBA | ||||
| MS 4A was included in the solvent. | |||||
| COMMENT | |||||
| Keywords: mannose-6-phosphate, M6P, N-linked glycans, eukaryotic cells, N-acetylglucosamine, GlcNAc, sequential deprotection | |||||
| There are multiple phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000321 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo2010999 | ||||
PubMed ID |
21955083 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (21): 8682-9. | ||||
Article Title |
Chemical synthesis of N-linked glycans carrying both mannose-6-phosphate and GlcNAc-mannose-6-phosphate motifs. | ||||
Author |
Yunpeng, Liu; Gong, Chen | ||||
Affiliation |
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States. | ||||
Reference Id |
REF-0000-000322 | ||||
Source |
J. Org. Chem., 2011, 76 (21), pp 8682-8689 | ||||
Doi |
10.1021/jo2010999 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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