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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002145 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002145
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Regist Date |
2012/06/21 18:39:38 | ||||
| REACTANT | |||||
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Mol |
0.16 to 0.234 mmol | ||||
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Reactant Type |
n-BuOH (solvent) | ||||
Volume |
5 mL | ||||
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Reactant Type |
ethylenediamine | ||||
Volume |
2.5 mL | ||||
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Reactant Type |
pyridine (solvent) | ||||
Volume |
5 mL | ||||
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Reactant Type |
Ac2O (solvent) | ||||
Volume |
5 mL | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
55%(at least) | ||||
| REACTION DETAIL | |||||
Reaction Time |
12 hours, 12 hours | ||||
Reaction Temp |
90 degree C, room temp | ||||
Solvent |
n-BuOH, pyridine/Ac2O | ||||
Comment |
1) 15+n-BuOH, ethylenediamine, 2) +all the rest | ||||
| COMMENT | |||||
| Keywords: mannose-6-phosphate, M6P, N-linked glycans, eukaryotic cells, N-acetylglucosamine, GlcNAc, sequential deprotection | |||||
| There are multiple phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000321 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo2010999 | ||||
PubMed ID |
21955083 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (21): 8682-9. | ||||
Article Title |
Chemical synthesis of N-linked glycans carrying both mannose-6-phosphate and GlcNAc-mannose-6-phosphate motifs. | ||||
Author |
Yunpeng, Liu; Gong, Chen | ||||
Affiliation |
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States. | ||||
Reference Id |
REF-0000-000322 | ||||
Source |
J. Org. Chem., 2011, 76 (21), pp 8682-8689 | ||||
Doi |
10.1021/jo2010999 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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