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Glycan Syntheses |
JCGG ID |
JCGG-RAC0002069 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-002069
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Regist Date |
2012/06/21 18:31:17 | ||||
| REACTANT | |||||
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Mol |
43 micro mole | ||||
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Reactant Type |
Me2NH (2 M in THF) | ||||
Mol |
0.64 + 1.1 + 0.86 mmol | ||||
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Reactant Type |
AcONH4 (pH 4.6 buffer, solvent) | ||||
Volume |
0.5 mL | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
67% | ||||
| REACTION DETAIL | |||||
Reaction Time |
69 hours, 10 hours | ||||
Reaction Temp |
room temp, room temp | ||||
Solvent |
dry MeCN/dry THF, AcONH4 buffer | ||||
Comment |
1) +all except AcONH4, 2) +AcONH4 | ||||
| Me2NH was added three times. (first phase; 0 hour, 6 hours, and 42 hours) | |||||
| COMMENT | |||||
| Keywords: alpha-D-glycosyl boranophosphate, phosphoramidite, condensation, boronation, terminal deprotection, Leishmania glycocalyx lipophosphoglycans | |||||
| There are multiple phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000315 | ||||
Issn |
Electronic | ||||
Doi |
10.1021/jo102584g | ||||
PubMed ID |
21381786 | ||||
Journal Name |
The Journal of organic chemistry. (2011) 76 (8): 2648-59. | ||||
Article Title |
Synthesis of oligo(α-D-glycosyl phosphate) derivatives by a phosphoramidite method via boranophosphate intermediates. | ||||
Author |
Shoichi, Fujita; Natsuhisa, Oka; Fumiko, Matsumura; Takeshi, Wada | ||||
Affiliation |
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan. | ||||
Reference Id |
REF-0000-000316 | ||||
Source |
J. Org. Chem. 2011, 76, 2648-2659 | ||||
Doi |
10.1021/jo102584g | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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