Reaction:JCGG-RAC0001816

JCGG ID

JCGG-RAC0001816

Submitter

The Noguchi Institute

Reaction ID

R-0000-001816

Regist Date

2012/06/21 18:02:55

REACTANT

MOLECULE ID

JCGG-COM0000469 (Reaction Tree)

Skeleton

JCGG-STR001961

Reactant Type

acceptor

Mol

1.34 mmol

MOLECULE ID

JCGG-COM0000629 (Reaction Tree)

Reactant Type

donor

Mol

2.01 mmol

MOLECULE ID

JCGG-COM0000129

Reactant Type

NIS

Mol

3.09 mmol

MOLECULE ID

JCGG-COM0000111

Reactant Type

TfOH

Mol

0.54 mmol

PRODUCT

MOLECULE ID

JCGG-COM0000472 (Reaction Tree)

Skeleton

JCGG-STR005020

Product Type

alpha

Yield

60%

MOLECULE ID

JCGG-COM0000471 (Reaction Tree)

Skeleton

JCGG-STR026331

Product Type

beta

Yield

11%

REACTION DETAIL

Reaction Time

6 hours

Reaction Temp

-35 degree C

Solvent

dry MeCN

Comment

19, 12, and MS 3A were mixed and stirred for 5 hours at room temperature before the reaction.

MS 3A was included in the solvent.

COMMENT

Keywords: synthesis, sialyl glycosides, sialylation, penta-O-benzyl-lactose

REFERENCE

Reference Id

REF-0000-000196

Source

PREPARATIVE CARBOHYDRATE CHEMISTRY

Reference Id

REF-0000-000197

Source

ISBN 0-8247-9802-3

Reference Id

REF-0000-000244

Source

J. Carbohydr. Chem. 10:493 (1991)

Reference Id

REF-0000-000246

Source

J. Carbohydr. Chem. 11:699 (1992)