JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0001738
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-001738
Regist Date
 2012/06/21 17:49:24
REACTANT
MOLECULE ID
 JCGG-COM0002069 (Reaction Tree)
Mol
 0.56 mmol
MOLECULE ID
 JCGG-COM0002274
Reactant Type
 HF*pyridine
Volume
 0.56 mL
MOLECULE ID
 JCGG-COM0000603
Reactant Type
 NBS
Mol
 0.62 mmol
PRODUCT
MOLECULE ID
 JCGG-COM0002070 (Reaction Tree)
Yield
 89%
REACTION DETAIL
Reaction Time
 1 hour
Reaction Temp
 -35 to 0 degree C
Solvent
 CH2Cl2
Comment
 The addition of HF*pyridine complex was performed before the addition of NBS.
The reactants were mixed at -35 degree in Celsius, and allowed to warm to 0 degree within the reaction time.
COMMENT
Keywords: glycosyl fluorides, glycosyl sulfides, globotriaosylceramide, Gb3
The reaction is the 1st part of the sequence.
REFERENCE
Reference Id
 REF-0000-000196
Source
 PREPARATIVE CARBOHYDRATE CHEMISTRY
Reference Id
 REF-0000-000197
Source
 ISBN 0-8247-9802-3
Reference Id
 REF-0000-000230
Source
 Carbohydr. Res. 202:177 (1990)
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)