JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0001735
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-001735
Regist Date
 2012/06/21 17:48:48
REACTANT
MOLECULE ID
 JCGG-COM0002267 (Reaction Tree)
Reactant Type
 (alpha/beta = 1/4)
Mol
 0.043 mmol
MOLECULE ID
 JCGG-COM0002268 (Reaction Tree)
Skeleton
JCGG-STR025761
Mol
 0.11 mmol
MOLECULE ID
 JCGG-COM0000624
Reactant Type
 AgOTf
Mol
 0.19 mmol
MOLECULE ID
 JCGG-COM0002263
Reactant Type
 Cp2HfCl2
Mol
 0.21 mmol
PRODUCT
MOLECULE ID
 JCGG-COM0002269 (Reaction Tree)
Yield
 37%
REACTION DETAIL
Reaction Time
 18 hours
Reaction Temp
 -20 to 25 degree C
Solvent
 CH2Cl2
Comment
 MS 4A was included in the solvent.
The reactants were mixed at -20 degree in Celsius, and allowed to warm to room temperature slowly within the reaction time.
COMMENT
Keywords: glycosyl fluorides, glycosyl sulfides, sialyl dimeric Lex
32% of unreacted fluoride (compound 34) was also obtained.
REFERENCE
Reference Id
 REF-0000-000196
Source
 PREPARATIVE CARBOHYDRATE CHEMISTRY
Reference Id
 REF-0000-000197
Source
 ISBN 0-8247-9802-3
Reference Id
 REF-0000-000228
Source
 J. Am. Chem. Soc. 114:3126 (1992)
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)