JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0001716
Submitter
The Noguchi Institute
Reaction ID
R-0000-001716
Regist Date
2012/06/21 17:42:56
REACTANT
MOLECULE ID
JCGG-COM0001950 (Reaction Tree)
Mol
1 mmol
MOLECULE ID
JCGG-COM0000071 (Reaction Tree)
Skeleton
JCGG-STR032525
Mol
1.2 mmol
MOLECULE ID
JCGG-COM0000099
Reactant Type
BF3*OEt2 (0.1 M in Et2O/CH2Cl2=1/1)
Volume
1 mL
PRODUCT
MOLECULE ID
JCGG-COM0001951 (Reaction Tree)
Yield
90%
REACTION DETAIL
Reaction Time
(5 to 10) + 15 minutes
Reaction Temp
0 degree C
Solvent
dry CH2Cl2
Comment
38, 39, and MS 4A were mixed and stirred for 30 minutes at room temperature before the reaction.
MS 4A was included in the solvent.
BF3*OEt2 was added dropwise within 5 to 10 minutes.
COMMENT
Keywords: glycosylation, O-glycosyl trichloroacetimidates
The reaction is the 1st part of the sequence.
REFERENCE
Reference Id
REF-0000-000196
Source
PREPARATIVE CARBOHYDRATE CHEMISTRY
Reference Id
REF-0000-000197
Source
ISBN 0-8247-9802-3
Reference Id
REF-0000-000216
Source
Synthesis p. 694 (1988)

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)