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Glycan Syntheses |
JCGG ID |
JCGG-RAC0001683 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001683
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Regist Date |
2012/06/21 17:36:52 | ||||
| REACTANT | |||||
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Reactant Type |
Fmoc-threonine (in dry CH2Cl2) | ||||
Mol |
0.138 mol | ||||
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Reactant Type |
DCC | ||||
Mol |
0.45 mol | ||||
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Reactant Type |
t-BuOH | ||||
Mol |
0.58 mol | ||||
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Reactant Type |
CuCl | ||||
Mol |
0.01 mol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
77% | ||||
| REACTION DETAIL | |||||
Reaction Time |
5 days, 4 hours | ||||
Reaction Temp |
room temp, NOT specified | ||||
Solvent |
dry CH2Cl2, dry CH2Cl2 | ||||
Comment |
1) +all except Fmoc threonine, 2) +Fmoc threonine | ||||
| Fmoc threonine was added dropwise. (second step) | |||||
| COMMENT | |||||
| Keywords: O-glycopeptide, N-glycopeptide, synthesis, selectively deprotected building blocks, fluorenylmethoxycarbonyl group, Fmoc, benzyl esters | |||||
| There are multiple steps in this reaction. | |||||
| ATTENTION: There is a numerical discrepancy between the scheme and the written method. (the reaction time) | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000196 | ||||
Source |
PREPARATIVE CARBOHYDRATE CHEMISTRY | ||||
Reference Id |
REF-0000-000197 | ||||
Source |
ISBN 0-8247-9802-3 | ||||
Reference Id |
REF-0000-000199 | ||||
Source |
H. Kunz and G. Braum, unpublished results; G. Braum, Synthese von Glycopeptiden mit photoaktivierbaren Gruppen im Saccharidteil, Dissertation, Universitat Mainz, Germany, 1991 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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