|
Glycan Syntheses |
JCGG ID |
JCGG-RAC0001531 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001531
|
||||
Regist Date |
2012/06/21 17:17:37 | ||||
| REACTANT | |||||
|
|
|
||||
Reactant Type |
glycal | ||||
Mol |
24 mmol | ||||
|
|
|
||||
Reactant Type |
PhSCl | ||||
Mol |
41 mmol | ||||
|
|
|
||||
Reactant Type |
Na2CO3 | ||||
Weight |
5g | ||||
| PRODUCT | |||||
MOLECULE ID |
|
|
|||
Yield |
80% | ||||
| REACTION DETAIL | |||||
Reaction Time |
NOT specified, 30 minutes, 1 hour | ||||
Reaction Temp |
room temp, room temp, 50 degree C | ||||
Solvent |
CCl4, THF/H2O = 1/1, THF/H2O = 1/1 | ||||
Comment |
1) glycal+PhSCl, 2) +Na2CO3, 3) temperature change | ||||
| The stirring continued until the glycal disappeared in TLC. (first step) | |||||
| COMMENT | |||||
| Keywords: The synthesis of 2-deoxy-glycoside, stereoselectivity control using C-2 substitution group | |||||
| There are multiple steps in this reaction. | |||||
| The reaction is the 1st part of the sequence. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000073 | ||||
Source |
第4版 実験化学講座 (26), 丸善 | ||||
Reference Id |
REF-0000-000074 | ||||
Source |
ISBN 4-621-03702-1 | ||||
Reference Id |
REF-0000-000168 | ||||
Source |
R. Preuss and R. R. Schmidt, Synthesis, 1988, 694 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
|