Reaction:JCGG-RAC0001502

JCGG ID

JCGG-RAC0001502

Submitter

The Noguchi Institute

Reaction ID

R-0000-001502

Regist Date

2012/06/21 17:13:20

REACTANT

MOLECULE ID

JCGG-COM0001874 (Reaction Tree)

Reactant Type

oxazoline

Mol

1.0 + 1.0 mmol

MOLECULE ID

JCGG-COM0001875 (Reaction Tree)

Skeleton

JCGG-STR032526

Reactant Type

alcohol

Mol

1.0 mmol

MOLECULE ID

JCGG-COM0000547

Reactant Type

p-TsOH*H2O

Weight

0.020g

PRODUCT

MOLECULE ID

JCGG-COM0001876 (Reaction Tree)

Yield

84%

REACTION DETAIL

Reaction Time

16 + 24 hours

Reaction Temp

60 degree C

Solvent

MeNO2/PhCH3 = 1/1

Comment

The second addition of the oxazoline was performed 16 hours after the start of the reaction.

COMMENT

Keywords: The synthesis of 2-aminoglycoside, beta-2-aminoglycoside

REFERENCE

Reference Id

REF-0000-000073

Source

第4版実験化学講座 (26), 丸善

Reference Id

REF-0000-000074

Source

ISBN 4-621-03702-1

Reference Id

REF-0000-000148

Source

C. Auge and A. Veyrieres, J. Chem. Soc., Perkin Trans. 1, 1977, 1343