JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0001393
Submitter
The Noguchi Institute
Reaction ID
R-0000-001393
Regist Date
2012/06/21 16:57:26
REACTANT
MOLECULE ID
JCGG-COM0001605 (Reaction Tree)
Mol
0.218 mmol
MOLECULE ID
JCGG-COM0001611 (Reaction Tree)
Mol
0.168 mmol
MOLECULE ID
JCGG-COM0001581
Reactant Type
TMS2NK (0.5 M in PhCH3)
Mol
NOT specified
PRODUCT
MOLECULE ID
JCGG-COM0001616 (Reaction Tree)
Yield
38%
REACTION DETAIL
Reaction Time
3 hours
Reaction Temp
-10 degree C
Solvent
THF
Comment
The reactants were mixed at -78 degree in Celsius, and gradually allowed to warm to -10 degree.
TMS2NK was added dropwise.
COMMENT
Keywords: Bisubstrate-type sialyltransferase inhibitors, CMP-NeuAc, N-acetyllactosamine, lactose, sialic acid, ST6N, ST3N
REFERENCE
Reference Id
REF-0000-000071
Issn
Print
Doi
10.1021/jo030042g
PubMed ID
12839452
Journal Name
The Journal of organic chemistry. (2003) 68 (14): 5602-13.
Article Title
Systematic syntheses and inhibitory activities of bisubstrate-type inhibitors of sialyltransferases.
Author
Hiroshi, Hinou; Xue-Long, Sun; Yukishige, Ito
Affiliation
RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Reference Id
REF-0000-000072
Source
J. Org. Chem. 2003, 68, 5602-5613
Doi
10.1021/jo030042g

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