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Glycan Syntheses |
JCGG ID |
JCGG-RAC0001389 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001389
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Regist Date |
2012/06/21 16:57:04 | ||||
| REACTANT | |||||
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Mol |
0.125 mmol | ||||
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Mol |
0.114 mmol | ||||
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Reactant Type |
MeOH | ||||
Mol |
0.15 mmol | ||||
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Reactant Type |
TMS2NK (0.5 M in PhCH3) | ||||
Mol |
0.15 mmol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
21% | ||||
| REACTION DETAIL | |||||
Reaction Time |
2.5 hours | ||||
Reaction Temp |
-10 degree C | ||||
Solvent |
THF | ||||
Comment |
The reactants were mixed at -78 degree in Celsius, and gradually allowed to warm to -10 degree. | ||||
| TMS2NK was added dropwise. | |||||
| COMMENT | |||||
| Keywords: Bisubstrate-type sialyltransferase inhibitors, CMP-NeuAc, N-acetyllactosamine, lactose, sialic acid, ST6N, ST3N | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000071 | ||||
Issn |
|||||
Doi |
10.1021/jo030042g | ||||
PubMed ID |
12839452 | ||||
Journal Name |
The Journal of organic chemistry. (2003) 68 (14): 5602-13. | ||||
Article Title |
Systematic syntheses and inhibitory activities of bisubstrate-type inhibitors of sialyltransferases. | ||||
Author |
Hiroshi, Hinou; Xue-Long, Sun; Yukishige, Ito | ||||
Affiliation |
RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. | ||||
Reference Id |
REF-0000-000072 | ||||
Source |
J. Org. Chem. 2003, 68, 5602-5613 | ||||
Doi |
10.1021/jo030042g | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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