JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0001210
Submitter
The Noguchi Institute
Reaction ID
R-0000-001216
Regist Date
2012/06/21 16:45:25
REACTANT
MOLECULE ID
JCGG-COM0001292
Reactant Type
MES-Na
MOLECULE ID
JCGG-COM0001293
MOLECULE ID
JCGG-COM0001366 (Reaction Tree)
MOLECULE ID
JCGG-COM0001294
Reactant Type
MeCN
PRODUCT
MOLECULE ID
JCGG-COM0001308 (Reaction Tree)
Yield
38%
REACTION DETAIL
Reaction Time
2 hours
Reaction Temp
NOT specified
Solvent
H2O
Comment
PBS buffer was added to keep the pH of the solution at 7.4.
MeCN was added over the reaction time.
COMMENT
Keywords: prostate specific antigen, PSA, N-linked glycan, peptide backbone, antibody, cancer, amino acid, keyhole limpet hemocyanin, KLH
REFERENCE
Reference Id
REF-0000-000061
Issn
Electronic
Doi
10.1021/ja8028137
PubMed ID
18798614
Journal Name
Journal of the American Chemical Society. (2008) 130 (41): 13598-607.
Article Title
Toward a prostate specific antigen-based prostate cancer diagnostic assay: preparation of keyhole limpet hemocyanin-conjugated normal and transformed prostate specific antigen fragments.
Author
Vadim Y, Dudkin; Justin S, Miller; Anna S, Dudkina; Christophe, Antczak; David A, Scheinberg; Samuel J, Danishefsky
Affiliation
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
Reference Id
REF-0000-000062
Source
J. AM. CHEM. SOC. 2008, 130, 13598-13607
Doi
10.1021/ja8028137

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)