JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0001198
Submitter
The Noguchi Institute
Reaction ID
R-0000-001204
Regist Date
2012/06/21 16:44:46
REACTANT
MOLECULE ID
JCGG-COM0001296 (Reaction Tree)
Mol
0.05 mmol
MOLECULE ID
JCGG-COM0001275
Reactant Type
BH3 (1 M in THF; solvent)
Mol
1.00 mmol
MOLECULE ID
JCGG-COM0001276
Reactant Type
Bu2BOTf (1 M in CH2Cl2)
Mol
0.15 mmol
PRODUCT
MOLECULE ID
JCGG-COM0001298 (Reaction Tree)
Yield
85%
REACTION DETAIL
Reaction Time
5 minutes, 2 hours
Reaction Temp
0 degree C, 0 degree C
Solvent
THF, THF
Comment
1) 32a+BH3, 2) +Bu2BOTf
COMMENT
Keywords: prostate specific antigen, PSA, N-linked glycan, peptide backbone, antibody, cancer, amino acid, keyhole limpet hemocyanin, KLH
There are two phases in this reaction.
REFERENCE
Reference Id
REF-0000-000061
Issn
Electronic
Doi
10.1021/ja8028137
PubMed ID
18798614
Journal Name
Journal of the American Chemical Society. (2008) 130 (41): 13598-607.
Article Title
Toward a prostate specific antigen-based prostate cancer diagnostic assay: preparation of keyhole limpet hemocyanin-conjugated normal and transformed prostate specific antigen fragments.
Author
Vadim Y, Dudkin; Justin S, Miller; Anna S, Dudkina; Christophe, Antczak; David A, Scheinberg; Samuel J, Danishefsky
Affiliation
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
Reference Id
REF-0000-000062
Source
J. AM. CHEM. SOC. 2008, 130, 13598-13607
Doi
10.1021/ja8028137

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)