JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0001173
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-001173
Regist Date
 2012/06/21 16:43:07
REACTANT
MOLECULE ID
 JCGG-COM0001330 (Reaction Tree)
Skeleton
JCGG-STR031569
Mol
 3.00 mmol
MOLECULE ID
 JCGG-COM0000420
Reactant Type
 9-BBN (0.5 M in THF)
Mol
 6.00 mmol
MOLECULE ID
 JCGG-COM0000418
Reactant Type
 NaOH (0.5 M in H2O)
Mol
 9.0 mmol
MOLECULE ID
 JCGG-COM0000421
Reactant Type
 H2O2 (30% in H2O)
Mol
 30.1 mmol
PRODUCT
MOLECULE ID
 JCGG-COM0001333 (Reaction Tree)
Skeleton
JCGG-STR031569
Yield
 95%
REACTION DETAIL
Reaction Time
 24 hours, 16 hours
Reaction Temp
 room temp, NOT specified
Solvent
 THF, THF
Comment
 1) 6+9-BBN, 2) +all the rest
The reactants were mixed at 0 degree in Celsius, and allowed to warm to room temperature. (first phase)
COMMENT
Keywords: cyclodextrin, drug delivery system, drug carrier, stacking effect, arbutin, doxorubicin
The DOI could not be found.
There are two phases in this reaction.
REFERENCE
Reference Id
 REF-0000-000059
Issn
 Print
PubMed ID
 18473917
Journal Name
 Medicinal chemistry (Shāriqah (United Arab Emirates)). (2008) 4 (3): 244-55.
Article Title
 Beta-cyclodextrin conjugates with glucose moieties designed as drug carriers: their syntheses, evaluations using concanavalin A and doxorubicin, and structural analyses by NMR spectroscopy.
Author
 Yoshiki, Oda; Natsumi, Kobayashi; Takashi, Yamanoi; Kaname, Katsuraya; Keiko, Takahashi; Kenjiro, Hattori
Affiliation
 The Noguchi Institute, 1-8-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan.
Reference Id
 REF-0000-000060
Source
 Medicinal Chemistry, 2008, 4, 244-255
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)