Reaction:JCGG-RAC0001156

JCGG ID		JCGG-RAC0001156
Submitter		The Noguchi Institute
Reaction ID		R-0000-001165
Regist Date		2012/06/21 16:42:45
REACTANT
MOLECULE ID		JCGG-COM0001321 (Reaction Tree)
	Mol	0.26 mmol
MOLECULE ID		JCGG-COM0000484
	Reactant Type	O3 (gas)
MOLECULE ID		JCGG-COM0000408
	Reactant Type	Ph3P
	Mol	0.88 mmol
MOLECULE ID		JCGG-COM0000485
	Reactant Type	NaClO2
	Mol	3.1 mmol
MOLECULE ID		JCGG-COM0000486
	Reactant Type	NaH2PO4
	Mol	0.8 mmol
MOLECULE ID		JCGG-COM0000487
	Reactant Type	2-methyl-2-butene
	Mol	1.2 mmol
PRODUCT
MOLECULE ID		JCGG-COM0001322 (Reaction Tree)
	Yield	85%
REACTION DETAIL
Reaction Time		5 hours, 19 hours, 24 hours
Reaction Temp		-78 degree C, room temp, NOT specified
Solvent		CH2Cl2, CH2Cl2, t-BuOH/H2O = 4mL/1mL
Comment		1) 4+O3, 2) +Ph3P, 3) +all the rest
		The reactants were mixed at -78 degree in Celsius, and allowed to warm to room temperature. (second phase)
COMMENT
Keywords: Crown ether, Spiroketal, 1-C-Vinylated glucose, Glycosylation
There are three phases in this reaction.
REFERENCE
Reference Id		REF-0000-000056
	Issn	Electronic
	PubMed ID	18794788
	Journal Name	Molecules (Basel, Switzerland). (2008) 13 (8): 1840-5.
	Article Title	Synthesis of a novel D-glucose-conjugated 15-crown-5 ether with a spiro ketal structure.
	Author	Takashi, Yamanoi; Yoshiki, Oda; Hitomi, Muraishi; Sho, Matsuda
	Affiliation	The Noguchi Institute, 1-8-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan. tyama@noguchi.or.jp
Reference Id		REF-0000-000057
	Source	Molecules 2008, 13, 1840-1845 manuscripts
	Doi	10.3390/molecules13081840