Reaction:JCGG-RAC0001151

JCGG ID		JCGG-RAC0001151
Submitter		The Noguchi Institute
Reaction ID		R-0000-001159
Regist Date		2012/06/21 16:42:25
REACTANT
MOLECULE ID		JCGG-COM0001314 (Reaction Tree)
	Mol	0.0057 mmol
MOLECULE ID		JCGG-COM0000756
	Reactant Type	NH3 (liquid)
MOLECULE ID		JCGG-COM0000160
	Reactant Type	Na (solid)
MOLECULE ID		JCGG-COM0001284
	Reactant Type	NH4Cl (solid)
MOLECULE ID		JCGG-COM0000549
	Reactant Type	NaHCO3 (sat. aq.)
MOLECULE ID		JCGG-COM0000086
	Reactant Type	Ac2O
PRODUCT
MOLECULE ID		JCGG-COM0001315 (Reaction Tree)
	Yield	81%
REACTION DETAIL
Reaction Time		10 + 120 minutes, 3 hours, 2 hours
Reaction Temp		-78 degree C, 25 degree C, room temp
Solvent		liquid NH3, NO solvent, Ac2O
Comment		1) NH3+Na, 26b, 2) +NH4Cl, 3) +all the rest
		26b was added 10 minutes after the start of the first phase.
COMMENT
Keywords: cancer, prostate gland, prostatic epithelium, prostate specific antigen, PSA, amino acid residues
There are three phases in this reaction.
REFERENCE
Reference Id		REF-0000-000054
	Issn	Print
	Doi	10.1021/ja037988s
	PubMed ID	14733546
	Journal Name	Journal of the American Chemical Society. (2004) 126 (3): 736-8.
	Article Title	Chemical synthesis of normal and transformed PSA glycopeptides.
	Author	Vadim Y, Dudkin; Justin S, Miller; Samuel J, Danishefsky
	Affiliation	Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Reference Id		REF-0000-000055
	Source	J. Am. Chem. Soc., 2004, 126 (3), pp 736-738
	Doi	10.1021/ja037988s