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Glycan Syntheses |
JCGG ID |
JCGG-RAC0001148 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001156
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Regist Date |
2012/06/21 16:42:11 | ||||
| REACTANT | |||||
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Mol |
0.044 mmol | ||||
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Mol |
0.455 mmol | ||||
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Reactant Type |
(BrC6H4)3NSbCl6 | ||||
Mol |
0.5 mmol (total) | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
19% | ||||
| REACTION DETAIL | |||||
Reaction Time |
40 minutes, 20 hours | ||||
Reaction Temp |
10 degree C, room temp | ||||
Solvent |
dry MeCN, dry MeCN | ||||
Comment |
1) 11+(BrC6H4)3NSbCl6, 9, 2) the second addition of (BrC6H4)3NSbCl6 | ||||
| MS 3A was included in the solvent. | |||||
| The reaction was conducted with exclusion of light. | |||||
| 9 was added dropwise. | |||||
| Before the reaction, 11 and 9 were prepared independently and stirred with MS 3A in MeCN for 1 hour at room temperature. | |||||
| COMMENT | |||||
| Keywords: cancer, prostate gland, prostatic epithelium, prostate specific antigen, PSA, amino acid residues | |||||
| (BrC6H4)3NSbCl6 = Tris(4-bromophenyl)aminium Hexachloroantimonate (CAS number: 24964-91-8) | |||||
| There are two phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000054 | ||||
Issn |
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Doi |
10.1021/ja037988s | ||||
PubMed ID |
14733546 | ||||
Journal Name |
Journal of the American Chemical Society. (2004) 126 (3): 736-8. | ||||
Article Title |
Chemical synthesis of normal and transformed PSA glycopeptides. | ||||
Author |
Vadim Y, Dudkin; Justin S, Miller; Samuel J, Danishefsky | ||||
Affiliation |
Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA. | ||||
Reference Id |
REF-0000-000055 | ||||
Source |
J. Am. Chem. Soc., 2004, 126 (3), pp 736-738 | ||||
Doi |
10.1021/ja037988s | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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