|
Glycan Syntheses |
JCGG ID |
JCGG-RAC0001136 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001138
|
||||
Regist Date |
2012/06/21 16:41:05 | ||||
| REACTANT | |||||
|
|
|
||||
Mol |
0.0227 mmol | ||||
|
|
|
||||
Reactant Type |
NH3 (liquid) | ||||
|
|
|
||||
Reactant Type |
Na (solid) | ||||
|
|
|
||||
Reactant Type |
NH4Cl (solid) | ||||
|
|
|
||||
Reactant Type |
NaHCO3 (sat. aq.) | ||||
|
|
|
||||
Reactant Type |
Ac2O | ||||
| PRODUCT | |||||
MOLECULE ID |
|
|
|||
Yield |
64% | ||||
| REACTION DETAIL | |||||
Reaction Time |
10 + 120 minutes, 3 hours, 2 hours | ||||
Reaction Temp |
-78 degree C, 25 degree C, room temp | ||||
Solvent |
liquid NH3, NO solvent, Ac2O | ||||
Comment |
1) NH3+Na, 14, 2) +NH4Cl, 3) +all the rest | ||||
| 14 was added 10 minutes after the start of the first phase. | |||||
| COMMENT | |||||
| Keywords: cancer, prostate gland, prostatic epithelium, prostate specific antigen, PSA, amino acid residues | |||||
| There are three phases in this reaction. | |||||
| ATTENTION: NaOMe appearing in Scheme 1 is not mentioned in the written method. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000054 | ||||
Issn |
|||||
Doi |
10.1021/ja037988s | ||||
PubMed ID |
14733546 | ||||
Journal Name |
Journal of the American Chemical Society. (2004) 126 (3): 736-8. | ||||
Article Title |
Chemical synthesis of normal and transformed PSA glycopeptides. | ||||
Author |
Vadim Y, Dudkin; Justin S, Miller; Samuel J, Danishefsky | ||||
Affiliation |
Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA. | ||||
Reference Id |
REF-0000-000055 | ||||
Source |
J. Am. Chem. Soc., 2004, 126 (3), pp 736-738 | ||||
Doi |
10.1021/ja037988s | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
|