Reaction:JCGG-RAC0001134

JCGG ID		JCGG-RAC0001134
Submitter		The Noguchi Institute
Reaction ID		R-0000-001134
Regist Date		2012/06/21 16:40:49
REACTANT
MOLECULE ID		JCGG-COM0001273 (Reaction Tree)
MOLECULE ID		JCGG-COM0001274 (Reaction Tree)
MOLECULE ID		JCGG-COM0001275
	Reactant Type	BH3*THF
MOLECULE ID		JCGG-COM0001276
	Reactant Type	Bu2BOTf
MOLECULE ID		JCGG-COM0001277
	Reactant Type	(BrC6H4)3NSbCl6
MOLECULE ID		JCGG-COM0000530
	Reactant Type	NaOMe
PRODUCT
MOLECULE ID		JCGG-COM0001278 (Reaction Tree)
	Yield	47.4%(72%, 74%, 89%)
REACTION DETAIL
Solvent		THF, MeCN, MeOH
Comment		1) 6+BH3*THF, Bu2BOTf, 2) +(BrC6H4)3NSbCl6, 3) +NaOMe
		Very few were described regarding this reaction.
COMMENT
Keywords: cancer, prostate gland, prostatic epithelium, prostate specific antigen, PSA, amino acid residues
There are three phases in this reaction.
(BrC6H4)3NSbCl6 = Tris(4-bromophenyl)aminium Hexachloroantimonate (CAS number: 24964-91-8)
REFERENCE
Reference Id		REF-0000-000054
	Issn	Print
	Doi	10.1021/ja037988s
	PubMed ID	14733546
	Journal Name	Journal of the American Chemical Society. (2004) 126 (3): 736-8.
	Article Title	Chemical synthesis of normal and transformed PSA glycopeptides.
	Author	Vadim Y, Dudkin; Justin S, Miller; Samuel J, Danishefsky
	Affiliation	Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Reference Id		REF-0000-000055
	Source	J. Am. Chem. Soc., 2004, 126 (3), pp 736-738
	Doi	10.1021/ja037988s