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Glycan Syntheses |
JCGG ID |
JCGG-RAC0001077 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001084
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Regist Date |
2012/06/21 16:38:20 | ||||
| REACTANT | |||||
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Reactant Type |
octasaccharide | ||||
Mol |
0.0150 mmol | ||||
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Reactant Type |
Na (in 7 mL of liquid NH3) | ||||
Mol |
2.43 mmol | ||||
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Reactant Type |
DMAP | ||||
Mol |
catalytic amount | ||||
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Reactant Type |
Ac2O | ||||
Volume |
0.3 mL | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
43% | ||||
| REACTION DETAIL | |||||
Reaction Time |
45 minutes, overnight, 15 minutes, 18 hours | ||||
Reaction Temp |
-78 degree C, room temp, room temp, room temp | ||||
Solvent |
anhydrous THF, MeOH, MeOH, DMF/THF/Et3N = (1 mL of each) | ||||
Comment |
1) Na+58, 2) +MeOH(solvent), 3) +Dowex 50-X8, 4) +all the rest | ||||
| Dowex50-X8 was added at the start of the third phase. | |||||
| COMMENT | |||||
| There are four phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000048 | ||||
Issn |
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PubMed ID |
11273599 | ||||
Journal Name |
Journal of the American Chemical Society. (2001) 123 (1): 35-48. | ||||
Article Title |
Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method. | ||||
Author |
H M, Kim; I J, Kim; S J, Danishefsky | ||||
Affiliation |
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Ave., New York, New York 10021, USA. | ||||
Reference Id |
REF-0000-000049 | ||||
Source |
J. Am. Chem. Soc. 2001, 123, 35-48 | ||||
Doi |
10.1021/ja0022730 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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