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Glycan Syntheses |
JCGG ID |
JCGG-RAC0001076 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-001083
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Regist Date |
2012/06/21 16:38:16 | ||||
| REACTANT | |||||
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Reactant Type |
azeotropically dried hexasaccharide | ||||
Mol |
0.0390 mmol | ||||
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Reactant Type |
fucosyl fluoride | ||||
Mol |
0.196 mmol | ||||
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Reactant Type |
di-tert-butylpyridine | ||||
Mol |
0.28 mmol | ||||
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Reactant Type |
Sn(OTf)2 (in 0.650 mL of THF) | ||||
Mol |
0.137 mmol | ||||
| PRODUCT | |||||
MOLECULE ID |
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Yield |
70% | ||||
| REACTION DETAIL | |||||
Reaction Time |
10 minutes, 24 hours | ||||
Reaction Temp |
room temp, -7 degree C | ||||
Solvent |
anhydrous PhCH3, anhydrous PhCH3 | ||||
Comment |
1) 57+23, MS 4A, di-tert-butylpyridine, 2) +Sn(OTf)2 | ||||
| MS 4A was included in the solvent. | |||||
| The reactants were mixed at -15 degree in Celsius, and allowed to warm to -7 degree. (second phase) | |||||
| COMMENT | |||||
| There are two phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000048 | ||||
Issn |
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PubMed ID |
11273599 | ||||
Journal Name |
Journal of the American Chemical Society. (2001) 123 (1): 35-48. | ||||
Article Title |
Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method. | ||||
Author |
H M, Kim; I J, Kim; S J, Danishefsky | ||||
Affiliation |
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Ave., New York, New York 10021, USA. | ||||
Reference Id |
REF-0000-000049 | ||||
Source |
J. Am. Chem. Soc. 2001, 123, 35-48 | ||||
Doi |
10.1021/ja0022730 | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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