Reaction:JCGG-RAC0001028

JCGG ID		JCGG-RAC0001028
Submitter		The Noguchi Institute
Reaction ID		R-0000-001030
Regist Date		2012/06/21 16:35:39
REACTANT
MOLECULE ID		JCGG-COM0001139 (Reaction Tree)
	Mol	1 equiv.
MOLECULE ID		JCGG-COM0000418
	Reactant Type	NaOH (0.01 M)
MOLECULE ID		JCGG-COM0001152
	Reactant Type	PamCysSer
	Mol	1.5 equiv.
MOLECULE ID		JCGG-COM0000426
	Reactant Type	Hunig's base (DIEA)
	Mol	4 equiv.
MOLECULE ID		JCGG-COM0001030
	Reactant Type	HATU
	Mol	2 equiv.
MOLECULE ID		JCGG-COM0001029
	Reactant Type	HOAT
	Mol	4 equiv.
PRODUCT
MOLECULE ID		JCGG-COM0001155 (Reaction Tree)
	Yield	56.94%(first/second=78%/73%)
REACTION DETAIL
Reaction Time		16 + 10 hours, 16 hours
Reaction Temp		NOT specified, room temp
Solvent		MeOH/H2O = 10mL/10mL, DMF
Comment		1) 26+NaOH, 2) +all the rest
		NaOH was added dropwise until the pH was constantly between 9 and 10. (first phase)
		5 more drops of NaOH were added 16 hours after the start of the first phase.
		DOWEX was added at the end of the first phase.
COMMENT
The PMID could not be found.
There are two phases in this reaction.
REFERENCE
Reference Id		REF-0000-000046
	Source	J. Am. Chem. Soc. 2000, 122, 7273-7279
	Doi	10.1021/ja0011820