JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0000859
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-000859
Regist Date
 2012/06/21 16:26:58
REACTANT
MOLECULE ID
 JCGG-COM0000986 (Reaction Tree)
Skeleton
JCGG-STR032134
Mol
 0.152 mmol
MOLECULE ID
 JCGG-COM0000987
Reactant Type
 Et2NH
Volume
 0.83 mL
MOLECULE ID
 JCGG-COM0000991
Reactant Type
 N-Boc-asparatic acid beta-benzyl ester
Mol
 46.9 micro mole
MOLECULE ID
 JCGG-COM0000578
Reactant Type
 HOBt
Mol
 74.1 micro mole
MOLECULE ID
 JCGG-COM0000946 (Reaction Tree)
Reactant Type
 EDC
Mol
 62.6 micro mole
PRODUCT
MOLECULE ID
 JCGG-COM0000992 (Reaction Tree)
Skeleton
JCGG-STR032134
Yield
 77%
REACTION DETAIL
Reaction Time
 7 hours, 20 minutes + 9 hours
Reaction Temp
 room temp, room temp
Solvent
 CH2Cl2, CH2Cl2
Comment
 1) 93+Et2NH, 2) +N-Boc-asparatic acid beta-benzyl ester, HOBt, EDC
The mixture was stirred for the initial 20 minutes at 0 degree in Celsius, and allowed to rise to room temperature within 9 hours. (second phase)
COMMENT
The PMID could not be found.
There are two phases in this reaction.
REFERENCE
Reference Id
 REF-0000-000038
Source
 J. Am. Chem. Soc. 1996, 118, 6826-6840
Doi
 10.1021/ja952265x
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)