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Glycan Syntheses |
JCGG ID |
JCGG-RAC0000852 | ||||
Submitter |
The Noguchi Institute | ||||
Reaction ID |
R-0000-000852
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Regist Date |
2012/06/21 16:26:33 | ||||
| REACTANT | |||||
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Reactant Type |
cis-4-hydroxy-D-proline | ||||
Mol |
3.8 mmol | ||||
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Reactant Type |
SOCl2 | ||||
Mol |
4.25 mmol | ||||
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Reactant Type |
CbzCl | ||||
Mol |
4.2 mmol | ||||
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Reactant Type |
DIEA | ||||
Mol |
9.2 mmol | ||||
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Reactant Type |
H2O | ||||
Volume |
3 mL | ||||
| PRODUCT | |||||
MOLECULE ID |
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Product Type |
N-Cbz-4-hydroxy-D-proline methyl ester | ||||
Yield |
82% | ||||
| REACTION DETAIL | |||||
Reaction Time |
22 hours, 12 hours | ||||
Reaction Temp |
reflux, room temp | ||||
Solvent |
MeOH, MeOH/H2O | ||||
Comment |
1) cis-4-hydroxy-D-proline+SOCl2, 2) +CbzCl, DIEA, H2O | ||||
| The reactants were mixed at 0 degree in Celsius, and stirred for 1 hour before undergoing reflux. (first phase) | |||||
| COMMENT | |||||
| The PMID could not be found. | |||||
| There are two phases in this reaction. | |||||
| REFERENCE | |||||
Reference Id |
REF-0000-000038 | ||||
Source |
J. Am. Chem. Soc. 1996, 118, 6826-6840 | ||||
Doi |
10.1021/ja952265x | ||||
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)
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