JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0000845
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-000845
Regist Date
 2012/06/21 16:26:08
REACTANT
MOLECULE ID
 JCGG-COM0000921 (Reaction Tree)
Skeleton
JCGG-STR032134
Reactant Type
 dissolved in 30% TFA in CH2Cl2 (2 mL)
Mol
 30 micro mole
MOLECULE ID
 JCGG-COM0000578
Reactant Type
 HOBt
Mol
 40 micro mole
MOLECULE ID
 JCGG-COM0000966
Reactant Type
 N-Fmoc-trans-4-hydroxy-L-proline
Mol
 40 micro mole
MOLECULE ID
 JCGG-COM0000946 (Reaction Tree)
Reactant Type
 EDC
Mol
 40 micro mole
MOLECULE ID
 JCGG-COM0000047
Reactant Type
 Et3N
Volume
 0.5 mL
PRODUCT
MOLECULE ID
 JCGG-COM0000967 (Reaction Tree)
Skeleton
JCGG-STR032134
Yield
 63%
REACTION DETAIL
Reaction Time
 1+15 hours
Reaction Temp
 room temp
Solvent
 CH2Cl2
Comment
 48 was evaporated in Vacuo before the reaction. (30 minutes)
Initially, 48 and Et3N were mixed and allowed to stand for 1 hour in order to neutralize the solution.
COMMENT
The PMID could not be found.
REFERENCE
Reference Id
 REF-0000-000038
Source
 J. Am. Chem. Soc. 1996, 118, 6826-6840
Doi
 10.1021/ja952265x
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)