JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
 JCGG-RAC0000842
Submitter
 The Noguchi Institute
Reaction ID
 R-0000-000842
Regist Date
 2012/06/21 16:25:59
REACTANT
MOLECULE ID
 JCGG-COM0000921 (Reaction Tree)
Skeleton
JCGG-STR032134
Reactant Type
 dissolved in 30% TFA in CH2Cl2 (1.5 mL)
Mol
 33.6 micro mole
MOLECULE ID
 JCGG-COM0000704
Reactant Type
 4-methylmorpholine
Mol
 70 micro mole
MOLECULE ID
 JCGG-COM0000961 (Reaction Tree)
Reactant Type
 dissolved in dry DMF (0.2 mL)
Mol
 40 micro mole
MOLECULE ID
 JCGG-COM0000578
Reactant Type
 HOBt
Mol
 67 micro mole
MOLECULE ID
 JCGG-COM0000946 (Reaction Tree)
Reactant Type
 EDC
Mol
 67 micro mole
PRODUCT
MOLECULE ID
 JCGG-COM0000962 (Reaction Tree)
Yield
 48%
REACTION DETAIL
Reaction Time
 16 hours
Reaction Temp
 room temp
Solvent
 DMF
Comment
 Before the reaction, 48 was evaporated in Vacuo, neutralized with 4-methylmorpholine, and stirred for 1 h at room temperature.
The reactants were mixed at -20 degree in Celsius, and gradually raised to room temperature within the reaction time.
4-methylmorpholine was added twice.
COMMENT
The PMID could not be found.
REFERENCE
Reference Id
 REF-0000-000038
Source
 J. Am. Chem. Soc. 1996, 118, 6826-6840
Doi
 10.1021/ja952265x
©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)