JCGGDB TOP Glycan Syntheses

Reaction

JCGG ID
JCGG-RAC0000645
Submitter
The Noguchi Institute
Reaction ID
R-0000-000645
Regist Date
2012/06/21 16:16:36
REACTANT
MOLECULE ID
JCGG-COM0000641 (Reaction Tree)
Mol
0.067 mmol
MOLECULE ID
JCGG-COM0000710
Reactant Type
aldehyde
Mol
0.043 mmol
MOLECULE ID
JCGG-COM0000708
Reactant Type
NaBH3CN
Mol
0.093 mmol
MOLECULE ID
JCGG-COM0000491
Reactant Type
AcOH
Volume
11 micro L
PRODUCT
MOLECULE ID
JCGG-COM0000711 (Reaction Tree)
Yield
73%
REACTION DETAIL
Reaction Time
48 hours, 3 hours
Reaction Temp
room temp, room temp
Solvent
0.2 M phosphate buffer, 0.2 M phosphate buffer
Comment
1) 7b+aldehyde, NaBH3CN, 2) +AcOH
COMMENT
There are two phases in this reaction.
REFERENCE
Reference Id
REF-0000-000028
Issn
Electronic
Doi
10.1021/jm8000696
PubMed ID
18841881
Journal Name
Journal of medicinal chemistry. (2008) 51 (21): 6665-81.
Article Title
Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors.
Author
Hajjaj H M, Abdu-Allah; Taichi, Tamanaka; Jie, Yu; Lu, Zhuoyuan; Magesh, Sadagopan; Takahiro, Adachi; Takeshi, Tsubata; Soerge, Kelm; Hideharu, Ishida; Makoto, Kiso
Affiliation
Department of Applied Bio-organic Chemistry, The United Graduate School of Agricultural Sciences, Gifu University, Gifu 501-1193, Japan.
Reference Id
REF-0000-000029
Source
J. Med. Chem., 2008, 51, 6665-6681
Doi
10.1021/jm8000696

©2008-2013 Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)